STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
l(3)05822Lethal (3) 05822, isoform A. (600 aa)    
Predicted Functional Partners:
cindr
CIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis.
  
 
  0.840
CG12093
AT02196p.
      
 0.838
CG14797
CG14797-PA.
      
 0.836
SNF4Agamma
SNF4/AMP-activated protein kinase gamma subunit (SNF4Agamma) encodes a protein involved in lipid metabolism, autophagy and response to starvation.
   
 
 0.819
alc
Alicorn, isoform A; Protein kinase binding. It is involved in the biological process described with: regulation of catalytic activity; maintenance of apical/basal cell polarity; neuron cellular homeostasis.
   
 
 0.804
CG8405
LD33689p; It is involved in the biological process described with: wing disc dorsal/ventral pattern formation; response to endoplasmic reticulum stress; positive regulation of ERAD pathway.
      
 0.790
EndoA
Endophilin-A; Endophilin A (EndoA) encodes an essential protein for synaptic vesicle endocytosis. It recruits or stabilizes the product of Synj (required for vesicle uncoating) to endocytic membranes.
   
 
0.731
CG13711
Uncharacterized protein; It is involved in the biological process described with: regulation of localization.
      
 0.680
TyrRS
tRNA binding; tyrosine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tyrosyl-tRNA aminoacylation.
   
  
 0.609
CG2246
GH23275p; Magnesium ion binding; ribose phosphate diphosphokinase activity. It is involved in the biological process described with: nucleotide biosynthetic process; 5-phosphoribose 1-diphosphate biosynthetic process; nucleoside metabolic process; purine nucleotide biosynthetic process.
    
 
 0.609
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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