STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
snRNP-U1-CU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). Regulat [...] (145 aa)    
Predicted Functional Partners:
SmD1
Small ribonucleoprotein particle protein SmD1 (SmD1) is an RNA binding protein that forms a heterodimeric sub-complex with SmD2. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing
   
 0.999
SmE
Probable small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5
   
 0.999
SmD3
Small ribonucleoprotein particle protein SmD3 (SmD3) is an RNA binding protein that forms a heterodimeric sub-complex with SmB. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. SmD3 also has a function in germline specification, as it is required for localization of osk to the posterior pole of the oocyte
   
 0.999
SmF
Small ribonucleoprotein particle protein SmF (SmF) is an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. SmF also forms a heterotrimeric sub-complex with SmE and SNRPG
   
 0.999
SmB
Small ribonucleoprotein particle protein SmB (SmB) is an RNA binding protein that forms a heterodimeric sub-complex with SmD3. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing; Belongs to the snRNP SmB/SmN family
   
 0.999
snRNP70K
U1 small nuclear ribonucleoprotein 70 kDa; Mediates the splicing of pre-mRNA by binding to the stem loop I region of U1-snRNA
   
 0.999
snf
U1 small nuclear ribonucleoprotein A; Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). Plays a role in regulating sex-lethal splicing; Belongs to the RRM U1 A/B'' family
   
 0.998
SmD2
Small ribonucleoprotein particle protein SmD2 (SmD2) is an RNA binding protein that forms a heterodimeric sub-complex with SmD1. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing
   
 0.998
SmG
Small nuclear ribonucleoprotein G is a Sm class protein and a common component of pre-mRNA processing U snRNPs. It forms the toroidal core of U snRNPs (Sm core domain) together with 6 related Sm proteins
   
 0.997
CG1646
Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing
   
 0.993
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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