STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG5023GH21596p; Actin binding. It is involved in the biological process described with: actomyosin structure organization. (169 aa)    
Predicted Functional Partners:
Mp20
Muscle-specific protein 20; It is involved in the biological process described with: myoblast fusion; regulation of myoblast fusion.
  
 
0.910
Tm2
Tropomyosin-2; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis.
   
 
 0.811
CG5177
Trehalose 6-phosphate phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
   
    0.750
TpnC25D
Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization.
   
 
 0.743
Mlc1
Myosin light chain alkali; Microfilament motor activity; calcium ion binding. It is involved in the biological process described with: muscle contraction; mesoderm development.
   
 
 0.737
Prm
Paramyosin, long form; Paramyosin (Prm) encodes a muscle protein found only in invertebrates. It dimerizes into a coiled-coil that occupies the interior of the thick filament. Its role is thought to be structural, although it can be phosphorylated and this is important for muscle function.
   
  
 0.731
Act87E
Actin-87E; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family.
   
 0.725
Zasp66
Z band alternatively spliced PDZ-motif protein 66 (Zasp66) encodes a scaffold protein that binds the product of Actn and localizes to Z-discs in muscle cells. It plays a role in muscle development, especially in myofibril assembly.
   
    0.720
up
Troponin T, skeletal muscle; Upheld (up) encodes the striated muscle protein Troponin T. Troponins T, C and I form a regulatory complex with Tropomyosin that is found at regular intervals along the thin (F-actin) filaments of the muscle sarcomere.
   
  
 0.674
Act57B
Actin-57B; Actin 57B (Act57B) is one of several actin genes in the Drosophila genome, and one of the few that encode myofibrillar actin. This essential gene is a transcriptional target of Mef2 and Cf2 and is expressed in all embryonic muscles and a subset of adult muscle.
   
 0.666
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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