STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rab11Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. (214 aa)    
Predicted Functional Partners:
Rip11
Rab11 interacting protein (Rip11) encodes a protein that belongs to Rab11 family interacting proteins (FIP family). It binds only to the GTP bound form of the product of Rab11, thus acting as its effector. It regulates Rhodopsin transport and cytokinesis.
  
 0.999
didum
Dilute class unconventional myosin (didum) encodes a class V unconventional myosin that binds actin and hydrolyzes ATP. It functions in mRNA localization in the oocyte, spermatid individualization during spermatogenesis, transport of pigment granules in photoreceptors and mitochondrial transport in neuronal cells; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.999
nuf
Nuclear fallout, isoform J; Nuclear fallout (nuf) encodes a cytoplasmic, coiled-coil protein that acts as an adaptor between the product of Rab11 and motor proteins in the recycling endosome pathway. It is required for early embryo cellularization, and for subsequent Rab11-dependent processes.
   
 0.999
Sec15
Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
    
 0.997
fwd
Four wheel drive (fwd) encodes a Golgi-localized lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It is involved in spermatocyte cytokinesis and male fertility; Belongs to the PI3/PI4-kinase family.
    
 
 0.996
Gdi
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.
   
 
 0.990
Sec5
Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.
    
 0.977
brun
Protein brunelleschi; Cooperates with Rab11 and fwd/PI4K to mediate the flow of membrane through the Golgi, which is required to support cleavage furrow ingression, therefore promoting cytokinesis in male meiotic cells.
    
 
 0.944
Exo70
Exocyst complex component 7; Required for exocytosis. Thought to function in intracellular vesicle targeting and docking before SNARE complex formation. Belongs to the EXO70 family.
    
 0.937
Arf51F
ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Promotes cell movement and remodeling of the actin cytoskeleton during compound eye morphogenesis. Required for normal ethanol-induced tolerance and preference. Probably after Efa6-mediated activation, counteracts ethanol-induced sedation.
   
 
 0.933
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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