STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
r-lOrotidine 5'-phosphate decarboxylase; Rudimentary-like (r-l) encodes an enzyme involved in the novo pyrimidine biosynthesis; In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (493 aa)    
Predicted Functional Partners:
Dhod
Dihydroorotate dehydrogenase (Dhod) encodes a protein that is associated with the inner mitochondrial membrane. It catalyzes the fourth step of de novo pyrimidine biosynthesis, which is required for normal cuticle formation and oogenesis.
  
 0.998
su(r)
Suppressor of rudimentary (su(r)) encodes a dihydropyrimidine dehydrogenase, the first step of pyrimidine catabolism. su(r) depletion does not produce visible phenotypes, but synergistic effects are exhibited by combining mutants with genes affecting pyrimidine biosynthesis and beta-alanine metabolism.
  
 0.994
l(2)k01209
ATP binding; kinase activity; uridine kinase activity. It is involved in the biological process described with: nucleoside metabolic process; pyrimidine-containing compound salvage.
   
 0.989
CG6330
GH09623p; Uridine phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process; gravitaxis; nucleotide catabolic process.
    
 0.983
CG3788
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
    
 0.983
CG17224
FI09636p; Uridine phosphorylase activity. It is involved in the biological process described with: nucleotide catabolic process; nucleoside metabolic process.
    
 0.974
kri
Krishah, isoform A; Krishah (kri) encodes a uracil phosphoribosyltransferase.
   
 0.974
Gart
Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family.
  
  
 0.962
r
Glutamine-dependent carbamoyl-phosphate synthase; Rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy.
  
 
 0.947
CG32576
Uncharacterized protein, isoform B; It is involved in the biological process described with: vesicle-mediated transport.
  
  
 0.938
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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