node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG6800 | CycH | FBpp0083530 | FBpp0078093 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | 0.930 |
CG6800 | Mat1 | FBpp0083530 | FBpp0087350 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. | 0.931 |
CG6800 | RpII215 | FBpp0083530 | FBpp0073387 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | 0.926 |
CG6800 | Ssl1 | FBpp0083530 | FBpp0078205 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | General transcription factor IIH subunit; Zinc ion binding; nucleic acid binding. | 0.901 |
CG6800 | TfIIEalpha | FBpp0083530 | FBpp0075839 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | Transcription factor IIEalpha (TfIIEalpha) encodes the large subunit of the RNA polymerase II general transcription factor TFIIE. The products of TfIIEalpha and TfIIEbeta are essential for transcription initiation in vitro acting with RNA polymerase II and the other general transcription factors. | 0.881 |
CG6800 | TfIIEbeta | FBpp0083530 | FBpp0073090 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | 0.898 |
CG6800 | Tfb1 | FBpp0083530 | FBpp0086678 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.902 |
CG6800 | Tfb4 | FBpp0083530 | FBpp0077650 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | Transcription factor B4; RNA polymerase II CTD heptapeptide repeat kinase activity; DNA-dependent ATPase activity. | 0.922 |
CG6800 | Xpd | FBpp0083530 | FBpp0071503 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | Xeroderma pigmentosum D (Xpd) encodes a DNA helicase that is a subunit of the basal transcription and DNA repair factor TFIIH. | 0.913 |
CG6800 | hay | FBpp0083530 | FBpp0075982 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is req [...] | 0.845 |
CycH | CG6800 | FBpp0078093 | FBpp0083530 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. | 0.930 |
CycH | Mat1 | FBpp0078093 | FBpp0087350 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. | 0.999 |
CycH | RpII215 | FBpp0078093 | FBpp0073387 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | 0.975 |
CycH | Ssl1 | FBpp0078093 | FBpp0078205 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | General transcription factor IIH subunit; Zinc ion binding; nucleic acid binding. | 0.997 |
CycH | TfIIEalpha | FBpp0078093 | FBpp0075839 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | Transcription factor IIEalpha (TfIIEalpha) encodes the large subunit of the RNA polymerase II general transcription factor TFIIE. The products of TfIIEalpha and TfIIEbeta are essential for transcription initiation in vitro acting with RNA polymerase II and the other general transcription factors. | 0.994 |
CycH | TfIIEbeta | FBpp0078093 | FBpp0073090 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | 0.992 |
CycH | Tfb1 | FBpp0078093 | FBpp0086678 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.997 |
CycH | Tfb4 | FBpp0078093 | FBpp0077650 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | Transcription factor B4; RNA polymerase II CTD heptapeptide repeat kinase activity; DNA-dependent ATPase activity. | 0.998 |
CycH | Xpd | FBpp0078093 | FBpp0071503 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | Xeroderma pigmentosum D (Xpd) encodes a DNA helicase that is a subunit of the basal transcription and DNA repair factor TFIIH. | 0.998 |
CycH | hay | FBpp0078093 | FBpp0075982 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is req [...] | 0.997 |