STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dndDead end (dnd) encodes an Arf-like3 GTPase that controls the targeting of exocytosis machinery to specific apical domains in fusion cells during the tracheal branch fusion process. (179 aa)    
Predicted Functional Partners:
unc-119
Protein unc-119 homolog; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization.
    
 
 0.992
CG14367
ARL2_Bind_BART domain-containing protein; It is involved in the biological process described with: cilium assembly.
   
 
 0.946
PrBP
Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta; 3',5'-cyclic-nucleotide phosphodiesterase activity; protein binding. It is involved in the biological process described with: mushroom body development; sensory perception of light stimulus.
   
 
 0.944
TBCC
Tubulin-binding cofactor C, isoform A; Tubulin binding. It is involved in the biological process described with: tubulin complex assembly; protein folding; post-chaperonin tubulin folding pathway; cell morphogenesis.
    
 
 0.906
Arfrp1
ADP-ribosylation factor related protein 1; GTP binding. It is involved in the biological process described with: protein localization to organelle; Golgi to plasma membrane protein transport; intracellular protein transport.
   
 
0.841
IFT20
Intraflagellar transport 20; It is involved in the biological process described with: centrosome localization; intraciliary transport; cilium assembly; protein localization to cilium.
   
 
 0.826
nompB
No mechanoreceptor potential B (nompB) encodes an essential component of the conserved intraflagellar transport mechanism, which is needed to extend cilia above the cell surface. nompB mutants have truncated, nonfunctional sensory cilia with consequent mechanosensory deficits.
   
 
 0.816
IFT57
Intraflagellar transport protein 57 homolog; Required for the formation of cilia; Belongs to the IFT57 family.
   
  
 0.763
Rab23
RH23273p; Rab23 (Rab23) encodes a member of the Rab family of small GTPases known to be involved in vesicle transport processes. It cooperates with the product of in and the core group of planar cell polarity genes. It contributes to restricting actin accumulation and thus, prehair initiation to a single site within each wing cell, and to regulate the number and orientation of hairs on the leg and the abdominal cuticle. In addition, it regulates the trafficking of the ligand encoded by hh in the germline stem cell niche.
    
 
 0.759
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
  
 
 0.750
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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