STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
klgLD10776p; Klingon (klg) encodes a homophilic cell adhesion molecule that is regulated by Notch signalling. It is involved in long term memory formation and photoreceptor cell commitment. (545 aa)    
Predicted Functional Partners:
CG3071
LD43561p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA processing; positive regulation of transcription by RNA polymerase I.
   
  
 0.917
dysf
Dysfusion, isoform D; Dysfusion (dysf) encodes a transcription factor that forms a DNA binding complex with the product of tgo to activate target genes. It is involved in in migration, adhesion, and fusion of tracheal cells, as well as tarsal joint formation during leg development.
   
  
 0.911
CG18478
Peptidase S1 domain-containing protein; It is involved in the biological process described with: proteolysis.
   
   0.865
CG14183
GH08353p; ATP binding.
 
 
   0.853
Gr32a
Gustatory and pheromone receptor 32a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily.
   
    0.852
SMC1
Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair.
   
   0.852
CG34228
HDC05827.
   
    0.852
CG31760
Probable G-protein coupled receptor CG31760; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway.
   
    0.852
CG43218
MIP12702p; Chitin binding. It is involved in the biological process described with: chitin metabolic process.
   
   0.850
CG30156
AT29763p; Hsp70 protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding; cellular response to misfolded protein; ubiquitin-dependent ERAD pathway.
   
    0.850
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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