STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG6204Uncharacterized protein; RNA binding. It is involved in the biological process described with: pericentric heterochromatin assembly; heterochromatin assembly by small RNA. (903 aa)    
Predicted Functional Partners:
jnj
Java no jive (jnj) encodes the Smc6 subunit of the SMC5/6 protein complex. It is involved genotoxic stress and response to caffeine.
   
  
 0.639
CG5877
Uncharacterized protein, isoform A; It is involved in the biological process described with: mRNA splicing, via spliceosome; heterochromatin assembly by small RNA; RNA interference.
   
  
 0.592
AGO2
Protein argonaute-2; Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger; Belongs to the argonaute family. Ago subfamily.
   
 
 0.535
AGO1
Argonaute-1, isoform A; Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both.
    
 
 0.534
Nse1
Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double- strand breaks (By similarity); Belongs to the NSE1 family.
   
  
 0.527
Trf4-2
Inactive non-canonical poly(A) RNA polymerase protein Trf4-2; Polynucleotide adenylyltransferase activity. It is involved in the biological process described with: histone mRNA catabolic process; nuclear polyadenylation-dependent ncRNA catabolic process; snoRNA polyadenylation; Belongs to the DNA polymerase type-B-like family.
    
 
 0.462
Trf4-1
Non-canonical poly(A) RNA polymerase protein Trf4-1; Involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Polyadenylates RNA processing and degradation intermediates of snRNAs and mRNAs.
    
 
 0.462
CG43181
Uncharacterized protein.
    
 
 0.459
Brms1
LD14895p; BRMS1 (Brms1) encodes a protein involved in regulation of the ecdysone signaling and the Notch signaling pathway in the wing.
      
 0.422
Adar
Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.
   
  
 0.417
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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