node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atg1 | Atg12 | FBpp0289788 | FBpp0289288 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Autophagy protein 12-like; Required for autophagy. | 0.998 |
Atg1 | Atg14 | FBpp0289788 | FBpp0084739 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | 0.999 |
Atg1 | Atg17 | FBpp0289788 | FBpp0306962 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan. | 0.999 |
Atg1 | Atg3 | FBpp0289788 | FBpp0074822 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy. | 0.998 |
Atg1 | Atg6 | FBpp0289788 | FBpp0083975 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. | 0.999 |
Atg1 | Atg9 | FBpp0289788 | FBpp0302990 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. | 0.995 |
Atg1 | Debcl | FBpp0289788 | FBpp0085443 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | 0.629 |
Atg1 | Pi3K59F | FBpp0289788 | FBpp0071973 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | 0.998 |
Atg1 | Uvrag | FBpp0289788 | FBpp0080039 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | UV-resistance associated gene (Uvrag) encodes a protein that regulates autophagy and vesicle trafficking with the product of Atg6 and class C vacuolar protein sorting complexes. With the products of Atg6 and Pi3K59F, It forms a PI3K(III) complex and plays roles in receptor downregulation and the establishment of proper cell polarity. It is also critical for proper organ rotation during development by controlling receptor endocytosis and subsequent degradation. | 0.839 |
Atg1 | Vps15 | FBpp0289788 | FBpp0081466 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. | 0.997 |
Atg12 | Atg1 | FBpp0289288 | FBpp0289788 | Autophagy protein 12-like; Required for autophagy. | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | 0.998 |
Atg12 | Atg14 | FBpp0289288 | FBpp0084739 | Autophagy protein 12-like; Required for autophagy. | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | 0.977 |
Atg12 | Atg17 | FBpp0289288 | FBpp0306962 | Autophagy protein 12-like; Required for autophagy. | Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan. | 0.973 |
Atg12 | Atg3 | FBpp0289288 | FBpp0074822 | Autophagy protein 12-like; Required for autophagy. | Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy. | 0.999 |
Atg12 | Atg6 | FBpp0289288 | FBpp0083975 | Autophagy protein 12-like; Required for autophagy. | Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. | 0.973 |
Atg12 | Atg9 | FBpp0289288 | FBpp0302990 | Autophagy protein 12-like; Required for autophagy. | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. | 0.977 |
Atg12 | Debcl | FBpp0289288 | FBpp0085443 | Autophagy protein 12-like; Required for autophagy. | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | 0.963 |
Atg12 | Pi3K59F | FBpp0289288 | FBpp0071973 | Autophagy protein 12-like; Required for autophagy. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | 0.989 |
Atg12 | Uvrag | FBpp0289288 | FBpp0080039 | Autophagy protein 12-like; Required for autophagy. | UV-resistance associated gene (Uvrag) encodes a protein that regulates autophagy and vesicle trafficking with the product of Atg6 and class C vacuolar protein sorting complexes. With the products of Atg6 and Pi3K59F, It forms a PI3K(III) complex and plays roles in receptor downregulation and the establishment of proper cell polarity. It is also critical for proper organ rotation during development by controlling receptor endocytosis and subsequent degradation. | 0.940 |
Atg12 | Vps15 | FBpp0289288 | FBpp0081466 | Autophagy protein 12-like; Required for autophagy. | Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. | 0.982 |