STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sosieSosie, isoform A; Sosie (sosie) encodes a protein that localizes to the plasma membrane in the germ line and the follicle cells during oogenesis. It interacts with the products of kst, jbug and chic, and helps localizing the product of kst and Actins. (186 aa)    
Predicted Functional Partners:
Urod
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
  
 0.934
Ppox
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
  
  
 0.889
CG33658
Uncharacterized protein.
      
 0.838
CG3368
DUF2428 domain-containing protein; It is involved in the biological process described with: tRNA methylation.
      
 0.794
fh
Frataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the frataxin family.
    
 
 0.700
l(3)02640
Lethal (3) 02640; Hydroxymethylbilane synthase activity. It is involved in the biological process described with: heme biosynthetic process; peptidyl-pyrromethane cofactor linkage.
  
  
 0.693
GluProRS
Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
     
 0.676
Mvl
Malvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling.
  
  
 0.605
Obp56c
Odorant-binding protein 56c, isoform B; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus.
      
 0.604
Pbgs
Delta-aminolevulinic acid dehydratase; Zinc ion binding; porphobilinogen synthase activity. It is involved in the biological process described with: heme biosynthetic process; Belongs to the ALAD family.
  
  
 0.575
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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