node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG6729 | ssh | FBpp0079708 | FBpp0084175 | Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity). | Protein phosphatase Slingshot; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth. | 0.512 |
CG6873 | Cdc42 | FBpp0074378 | FBpp0301153 | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | 0.916 |
CG6873 | LIMK1 | FBpp0074378 | FBpp0073493 | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | LIM domain kinase 1 (LIMK1) encodes a protein that belongs to a phylogenetically conserved family of serine/threonine kinases. It is a potent stabilizer of the actin cytoskeleton by inactivating the product of tsr. It stabilizes the synapse structure at the neuromuscular junction and promotes synaptic remodeling and glomerular development in the developing antennal lobe. | 0.990 |
CG6873 | cdi | FBpp0074378 | FBpp0083130 | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | Center divider (cdi) encodes a serine/threonine kinase that stimulates the formation of actin fibers and focal adhesions through phosphorylation of the F-actin depolimerization factor tsr. | 0.461 |
CG6873 | p38a | FBpp0074378 | FBpp0083966 | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. | 0.440 |
CG6873 | ssh | FBpp0074378 | FBpp0084175 | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | Protein phosphatase Slingshot; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth. | 0.658 |
Cdc42 | CG6873 | FBpp0301153 | FBpp0074378 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | 0.916 |
Cdc42 | LIMK1 | FBpp0301153 | FBpp0073493 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | LIM domain kinase 1 (LIMK1) encodes a protein that belongs to a phylogenetically conserved family of serine/threonine kinases. It is a potent stabilizer of the actin cytoskeleton by inactivating the product of tsr. It stabilizes the synapse structure at the neuromuscular junction and promotes synaptic remodeling and glomerular development in the developing antennal lobe. | 0.938 |
Cdc42 | p38a | FBpp0301153 | FBpp0083966 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. | 0.819 |
Cdc42 | p38b | FBpp0301153 | FBpp0080111 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | P38b MAP kinase (p38b) encodes the serine/threonine kinase that constitutes MAP kinase signaling cascades. It is phosphorylated by MAPK kinases and phosphorylates various substrates that play roles in stress responses, immune responses and differentiation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. | 0.650 |
Cdc42 | ssh | FBpp0301153 | FBpp0084175 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | Protein phosphatase Slingshot; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth. | 0.523 |
Cdc42 | tsr | FBpp0301153 | FBpp0072097 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | Cofilin/actin-depolymerizing factor homolog; Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics. Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation. Promotes cell motility during ovary development and oogenesis. During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles. Also required for border cell migration during oogenesis. During border cell migration, required for actin tu [...] | 0.935 |
Erk7 | ssh | FBpp0071264 | FBpp0084175 | Extracellular signal-regulated kinase 7; Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53. | Protein phosphatase Slingshot; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth. | 0.527 |
LIMK1 | CG6873 | FBpp0073493 | FBpp0074378 | LIM domain kinase 1 (LIMK1) encodes a protein that belongs to a phylogenetically conserved family of serine/threonine kinases. It is a potent stabilizer of the actin cytoskeleton by inactivating the product of tsr. It stabilizes the synapse structure at the neuromuscular junction and promotes synaptic remodeling and glomerular development in the developing antennal lobe. | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | 0.990 |
LIMK1 | Cdc42 | FBpp0073493 | FBpp0301153 | LIM domain kinase 1 (LIMK1) encodes a protein that belongs to a phylogenetically conserved family of serine/threonine kinases. It is a potent stabilizer of the actin cytoskeleton by inactivating the product of tsr. It stabilizes the synapse structure at the neuromuscular junction and promotes synaptic remodeling and glomerular development in the developing antennal lobe. | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | 0.938 |
LIMK1 | ssh | FBpp0073493 | FBpp0084175 | LIM domain kinase 1 (LIMK1) encodes a protein that belongs to a phylogenetically conserved family of serine/threonine kinases. It is a potent stabilizer of the actin cytoskeleton by inactivating the product of tsr. It stabilizes the synapse structure at the neuromuscular junction and promotes synaptic remodeling and glomerular development in the developing antennal lobe. | Protein phosphatase Slingshot; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth. | 0.890 |
LIMK1 | tsr | FBpp0073493 | FBpp0072097 | LIM domain kinase 1 (LIMK1) encodes a protein that belongs to a phylogenetically conserved family of serine/threonine kinases. It is a potent stabilizer of the actin cytoskeleton by inactivating the product of tsr. It stabilizes the synapse structure at the neuromuscular junction and promotes synaptic remodeling and glomerular development in the developing antennal lobe. | Cofilin/actin-depolymerizing factor homolog; Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics. Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation. Promotes cell motility during ovary development and oogenesis. During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles. Also required for border cell migration during oogenesis. During border cell migration, required for actin tu [...] | 0.996 |
Nmd3 | ssh | FBpp0070409 | FBpp0084175 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | Protein phosphatase Slingshot; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth. | 0.512 |
cdi | CG6873 | FBpp0083130 | FBpp0074378 | Center divider (cdi) encodes a serine/threonine kinase that stimulates the formation of actin fibers and focal adhesions through phosphorylation of the F-actin depolimerization factor tsr. | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | 0.461 |
cdi | ssh | FBpp0083130 | FBpp0084175 | Center divider (cdi) encodes a serine/threonine kinase that stimulates the formation of actin fibers and focal adhesions through phosphorylation of the F-actin depolimerization factor tsr. | Protein phosphatase Slingshot; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth. | 0.651 |