STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
jigr1Jing interacting gene regulatory 1 (jigr1) encodes a nuclear protein that is differentially expressed in the embryonic central nervous system and highly expressed in neurons and glial cells in the larval nervous system. Its expression is downregulated in larval neuroblasts by the miR-92 family to maintain the neuroblast pool. (336 aa)    
Predicted Functional Partners:
CG14074
IP10578p.
   
   0.994
lwr
Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo.
   
   0.994
jing
Zinc finger protein jing; May functionally interact with Polycomb group (PcG) and trithorax group (trxG) proteins to repress transcription (Probable). Required for Egfr pathway function and MAPK activity in CNS midline and tracheal placodes and for CNS axon development and tracheal tubule development. Required to establish the primary axon scaffold in the brain and for lateral positioning of longitudinal glia, longitudinal axons and neurons. Required for glial survival. Required to establish the proximo-distal axis of the developing leg and for wing vein and alula development. Required [...]
   
  
 0.940
CG8281
GM10231p.
   
  
 0.672
Zif
Zinc-finger protein (Zif) encodes a C2H2-type zinc-finger transcription factor that is required for cell polarity and neuroblast self-renewal by regulating the expression and asymmetric localization of the product of aPKC. The phosphorylated product of Zif by aPKC is excluded from the nucleus, thus being the inactive form.
   
  
 0.624
CG14395
Uncharacterized protein, isoform B.
      
 0.608
CG15514
LD24318p; DNA binding.
   
 
 0.579
CG8924
LD19131p; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
  
 0.550
CG11723
LD29420p; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
 
 0.537
CG10949
GH22016p; It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
  
 0.498
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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