STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
roHomeobox protein rough; Required to establish the unique cell identity of photoreceptors R2 and R5 and consequently for ommatidial assembly in the developing eye imaginal disk. Repression of expression in R8 photoreceptor by senseless (sens) is an essential mechanism of R8 cell fate determination. (350 aa)    
Predicted Functional Partners:
Nf-YB
Nuclear factor Y-box B (Nf-YB) encodes a subunit of the nuclear transcription factor Y, which binds to the CCAAT box regulatory sequence. It regulates gene transcription and is involved in eye and thorax development.
      
 0.661
PGRP-LA
Peptidoglycan-recognition protein LA; Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response.
      
 0.603
exd
Homeobox protein extradenticle; Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.
    
 
 0.515
GC2
Glutamate carrier 2, isoform B; Glutamate Carrier 2 (GC2) encodes a protein of the inner mitochondrial membrane that catalyzes the transport of L-glutamate across the inner mitochondrial membrane. GC2 expression is confined to the testes.
      
 0.491
ato
Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.
   
 
 0.465
amos
Basic helix-loop-helix transcription factor amos; Transcription factor involved in early neurogenesis; sensillum basiconica formation and maybe sensillum trichodea development. Promotes multiple dendritic (MD) neuron formation. Required for olfactory sensilla; regulated by lozenge (lz).
    
 
 0.439
osa
Trithorax group protein osa; Trithorax group (trxG) protein required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. Required for the activation of genes such as Antp, Ubx and Eve. Binds to DNA without specific affinity, suggesting that it is recruited to promoters by promoter-specific proteins. Essential component of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. Thi [...]
    
 
 0.435
CG5355
LP07359p; Serine-type endopeptidase activity; endopeptidase activity; serine-type exopeptidase activity; oligopeptidase activity; carboxylic ester hydrolase activity. It is involved in the biological process described with: proteolysis.
      
 0.431
CG2528
Uncharacterized protein, isoform E; Serine-type exopeptidase activity; oligopeptidase activity; endopeptidase activity; serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis.
      
 0.431
GCS1
Glucosidase 1, isoform B; Mannosyl-oligosaccharide glucosidase activity. It is involved in the biological process described with: protein N-linked glycosylation; oligosaccharide metabolic process.
      
 0.430
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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