STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slu7Pre-mRNA-splicing factor Slu7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. (574 aa)    
Predicted Functional Partners:
Prp18
Putative mRNA splicing factor; It is involved in the biological process described with: generation of catalytic spliceosome for second transesterification step; mRNA splicing, via spliceosome; nuclear retention of unspliced pre-mRNA at the site of transcription.
  
 
 0.999
l(1)G0007
Lethal (1) G0007 (l(1)G0007) encodes a protein involved in alternative mRNA splicing regulation.
   
 0.998
CG6015
LD21931p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.998
Prp8
pre-mRNA processing factor 8 (Prp8) is an essential gene that encodes the largest and most highly conserved splicing factor. It is a core component of the U5 snRNP, with a key function in pre-mRNA processing catalyzed by the spliceosome.
   
 
 0.994
crn
Crooked neck (crn) encodes a component of the splicing complex involved in axon ensheathment, glial cell migration and Malpighian tubule morphogenesis; Belongs to the crooked-neck family.
   
 
 0.993
Cdc5
Cell division cycle 5, isoform A; DNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 
 0.993
l(3)72Ab
Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily.
   
 
 0.993
Cwc25
LD47748p; It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 
 0.993
pea
ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (By similarity). Before and after egg-chamber formation, required for nurse-cell chromatin dispersal (NCCD) probably by playing a role in spliceosome localization to chromatin/interchromatin spaces.
   
 
 0.992
l(1)10Bb
L(1)10Bb protein; It is involved in the biological process described with: mRNA splicing, via spliceosome.
    
 
 0.991
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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