node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldh-III | N | FBpp0300518 | FBpp0070483 | Aldehyde dehydrogenase type III (Aldh-III) encodes a protein that confers a xenobiotic stress resistance by oxidising aromatic aldehydes (benzaldehyde). It also neutralises the lipid aldehydes formed after the attack of reactive oxygen and radicals, such as malondialdehyde during lipid peroxidation. The catalytic redox reaction uses NAD(P)+ as a cofactor. | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | 0.475 |
Aldh-III | Tace | FBpp0300518 | FBpp0084917 | Aldehyde dehydrogenase type III (Aldh-III) encodes a protein that confers a xenobiotic stress resistance by oxidising aromatic aldehydes (benzaldehyde). It also neutralises the lipid aldehydes formed after the attack of reactive oxygen and radicals, such as malondialdehyde during lipid peroxidation. The catalytic redox reaction uses NAD(P)+ as a cofactor. | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.626 |
Ance | Tace | FBpp0080130 | FBpp0084917 | Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides. | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.907 |
Ance-2 | Tace | FBpp0080131 | FBpp0084917 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.677 |
Ance-3 | Tace | FBpp0310234 | FBpp0084917 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.596 |
Ance-4 | Tace | FBpp0087745 | FBpp0084917 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.582 |
Ance-5 | Tace | FBpp0072325 | FBpp0084917 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.588 |
N | Aldh-III | FBpp0070483 | FBpp0300518 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | Aldehyde dehydrogenase type III (Aldh-III) encodes a protein that confers a xenobiotic stress resistance by oxidising aromatic aldehydes (benzaldehyde). It also neutralises the lipid aldehydes formed after the attack of reactive oxygen and radicals, such as malondialdehyde during lipid peroxidation. The catalytic redox reaction uses NAD(P)+ as a cofactor. | 0.475 |
N | Nct | FBpp0070483 | FBpp0306637 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | 0.985 |
N | Tace | FBpp0070483 | FBpp0084917 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.903 |
Nct | N | FBpp0306637 | FBpp0070483 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | 0.985 |
Nct | Tace | FBpp0306637 | FBpp0084917 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.604 |
Rsf1 | Tace | FBpp0305603 | FBpp0084917 | RNA-binding protein Rsf1; May control important aspects of development. | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.652 |
Tace | Aldh-III | FBpp0084917 | FBpp0300518 | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | Aldehyde dehydrogenase type III (Aldh-III) encodes a protein that confers a xenobiotic stress resistance by oxidising aromatic aldehydes (benzaldehyde). It also neutralises the lipid aldehydes formed after the attack of reactive oxygen and radicals, such as malondialdehyde during lipid peroxidation. The catalytic redox reaction uses NAD(P)+ as a cofactor. | 0.626 |
Tace | Ance | FBpp0084917 | FBpp0080130 | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides. | 0.907 |
Tace | Ance-2 | FBpp0084917 | FBpp0080131 | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.677 |
Tace | Ance-3 | FBpp0084917 | FBpp0310234 | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.596 |
Tace | Ance-4 | FBpp0084917 | FBpp0087745 | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.582 |
Tace | Ance-5 | FBpp0084917 | FBpp0072325 | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.588 |
Tace | N | FBpp0084917 | FBpp0070483 | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | 0.903 |