STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp4c3Cytochrome P450 4c3; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (535 aa)    
Predicted Functional Partners:
Cpr
NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). May function to clear the olfactory organ (antennae) from accumulating chemicals. In the N-terminal section; belongs to the flavodoxin family.
 
  
 
 0.909
CG13667
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family.
 
  
 
 0.883
CG7798
GEO02684p1; Lysozyme activity. It is involved in the biological process described with: defense response to Gram-negative bacterium; Belongs to the glycosyl hydrolase 22 family.
      
 0.602
CG42237
Uncharacterized protein, isoform A; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process.
   
 
 0.566
CG3662
LD27268p; Amyloid-beta binding. It is involved in the biological process described with: multicellular organism reproduction; negative regulation of amyloid precursor protein biosynthetic process.
      
 0.522
Ugt37E1
UDP-glycosyltransferase family 37 member E1; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity.
   
 
 0.504
Ugt37B1
UDP-glycosyltransferase family 37 member B1; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity. It is involved in the biological process described with: UDP-glucose metabolic process.
   
 
 0.499
Ugt37C2
UDP-glycosyltransferase family 37 member C2, isoform A; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity.
   
 
 0.498
CG11159
GEO12014p1; Lysozyme activity. It is involved in the biological process described with: defense response to Gram-negative bacterium; Belongs to the glycosyl hydrolase 22 family.
      
 0.497
Sb
Serine proteinase stubble non-catalytic chain; Hormone dependent protease required for epithelial morphogenesis, including the formation of bristles, legs, and wings. Has a dual function, detaches imaginal disk cells from extracellular matrices through its extracellular proteolytic domain and transmits an outside-to-inside signal to its intracellular domain to modify the cytoskeleton during morphogenesis; Belongs to the peptidase S1 family.
    
 
 0.497
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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