STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Map205Microtubule-associated protein 205 (Map205) encodes a protein that binds and stabilizes microtubules. It also binds, inhibits and stabilizes the product of polo on microtubules during interphase. (1185 aa)    
Predicted Functional Partners:
polo
Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
   
 
 0.943
sigmar
Tumor necrosis factor alpha-induced protein 8-like protein; Salivary glands marred (sigmar) encodes a TNFAIP8-like (TIPE) protein family member. Its expression levels are responsive to the TNF ligand encoded by egr. The product of sigmar contribute to JNK signaling modulation, cytoskeletal remodeling and autophagy.
   
  
 0.761
CG2053
IP11148p; It is involved in the biological process described with: negative regulation of translation; mRNA catabolic process.
    
 
 0.678
bora
Aurora borealis (bora) encodes a binding partner of the product of aurA. It is required for spindle orientation and asymmetric cell division; Belongs to the BORA family.
      
 0.649
CG4362
MIP22975p.
    
 
 0.623
Rcd6
Reduction in Cnn dots 6, isoform A; It is involved in the biological process described with: centrosome cycle.
      
 0.609
hop
Tyrosine-protein kinase hopscotch; Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair- rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation.
   
   0.563
CG7546
Uncharacterized protein, isoform D; Enzyme binding; misfolded protein binding; polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: negative regulation of apoptotic process; ubiquitin-dependent ERAD pathway.
   
 
 0.545
lili
Lilipod (lili) encodes a multi-pass transmembrane protein required for Dpp signal transduction in the female germline to promote ovarian stem cell maintenance; Belongs to the LIMR family.
    
 
 0.534
aurB
Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis.
    
 
 0.529
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (36%) [HD]