STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ac3Adenylate cyclase 3 (Ac3) encodes an adenylate cyclase that is coupled to the receptor encoded by Pdfr via Gs signaling in the Morning circadian pacemakers. (1167 aa)    
Predicted Functional Partners:
Ir75c
Ionotropic glutamate receptor activity; signaling receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus involved in sensory perception.
      
 0.838
Or35a
Odorant receptor 35a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters. Involved in the behavioral responses to butanol, pentanol, hexanol, octanol, propyl acetate, and butyl acetate.
      
 0.836
Ir75b
Ionotropic receptor 75b; Ligand-gated ion channel activity; ionotropic glutamate receptor activity. It is involved in the biological process described with: detection of chemical stimulus involved in sensory perception.
      
 0.797
Ir84a
Ionotropic receptor 84a (Ir84a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of phenylacetic acid and controls male courtship behavior.
      
 0.674
Ir75a
Ionotropic receptor 75a; Odorant receptor for acetic and propionic acid. Functions as part of an olfactory receptor complex including the ionotropic receptor coreceptor Ir8a; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
      
 0.669
Ac13E
Adenylyl cyclase 13E, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway.
  
0.634
Galphaf
G protein alpha f subunit (Galphaf) encodes a transcriptional target of the JAK/STAT pathway in blood cells where it regulates cell shape and function; Belongs to the G-alpha family.
   
 0.616
Ir75d
Ionotropic glutamate receptor activity; ligand-gated ion channel activity; signaling receptor activity. It is involved in the biological process described with: detection of chemical stimulus involved in sensory perception.
      
 0.602
CG42514
GH08173p; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport.
      
 0.601
Pdfr
PDF receptor; Pigment-dispersing factor receptor (Pdfr) encodes a G-Protein Coupled Receptor in the Family B class of GPCRs (Secretin Receptor-like) that can be activated by the product of Pdf. It has been implicated in regulation of circadian physiology, development of the flight motor system, and regulation of mating.
    
 
 0.591
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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