STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CycKCyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by RpII215) and contributes to pre-mRNA processing, transcription and chromatin structure. (400 aa)    
Predicted Functional Partners:
Cdk9
Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control.
   
 0.999
Cdk12
Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
   
 0.999
Lim1
LIM homeobox 1 (Lim1) encodes a transcription factor protein involved in eye development and leg morphogenesis.
    
   0.994
CG32548
RE70879p.
    
   0.994
hale
Hale-bopp.
    
   0.994
CG15262
FI22161p1; poly(A)-specific ribonuclease activity. It is involved in the biological process described with: negative regulation of translation; regulation of transcription, DNA-templated; nuclear-transcribed mRNA poly(A) tail shortening; regulation of stem cell population maintenance.
   
   0.994
trv
Trivet, isoform I; Nucleic acid binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome.
    
   0.994
CycH
Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II.
   
 
 0.970
Spt5
Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development; Belongs [...]
   
 0.949
RpII215
DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...]
   
 0.948
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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