node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG15262 | CG32548 | FBpp0080292 | FBpp0074340 | FI22161p1; poly(A)-specific ribonuclease activity. It is involved in the biological process described with: negative regulation of translation; regulation of transcription, DNA-templated; nuclear-transcribed mRNA poly(A) tail shortening; regulation of stem cell population maintenance. | RE70879p. | 0.994 |
CG15262 | CycK | FBpp0080292 | FBpp0310472 | FI22161p1; poly(A)-specific ribonuclease activity. It is involved in the biological process described with: negative regulation of translation; regulation of transcription, DNA-templated; nuclear-transcribed mRNA poly(A) tail shortening; regulation of stem cell population maintenance. | Cyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by RpII215) and contributes to pre-mRNA processing, transcription and chromatin structure. | 0.994 |
CG15262 | RpII215 | FBpp0080292 | FBpp0073387 | FI22161p1; poly(A)-specific ribonuclease activity. It is involved in the biological process described with: negative regulation of translation; regulation of transcription, DNA-templated; nuclear-transcribed mRNA poly(A) tail shortening; regulation of stem cell population maintenance. | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | 0.747 |
CG32548 | CG15262 | FBpp0074340 | FBpp0080292 | RE70879p. | FI22161p1; poly(A)-specific ribonuclease activity. It is involved in the biological process described with: negative regulation of translation; regulation of transcription, DNA-templated; nuclear-transcribed mRNA poly(A) tail shortening; regulation of stem cell population maintenance. | 0.994 |
CG32548 | CycK | FBpp0074340 | FBpp0310472 | RE70879p. | Cyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by RpII215) and contributes to pre-mRNA processing, transcription and chromatin structure. | 0.994 |
CG32548 | Lim1 | FBpp0074340 | FBpp0071216 | RE70879p. | LIM homeobox 1 (Lim1) encodes a transcription factor protein involved in eye development and leg morphogenesis. | 0.994 |
CG32548 | hale | FBpp0074340 | FBpp0074681 | RE70879p. | Hale-bopp. | 0.994 |
Cdk12 | Cdk9 | FBpp0078014 | FBpp0071848 | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control. | 0.813 |
Cdk12 | CycH | FBpp0078014 | FBpp0078093 | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | 0.932 |
Cdk12 | CycK | FBpp0078014 | FBpp0310472 | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Cyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by RpII215) and contributes to pre-mRNA processing, transcription and chromatin structure. | 0.999 |
Cdk12 | RpII215 | FBpp0078014 | FBpp0073387 | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | 0.982 |
Cdk12 | Spt5 | FBpp0078014 | FBpp0085716 | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development; Belongs [...] | 0.992 |
Cdk9 | Cdk12 | FBpp0071848 | FBpp0078014 | Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control. | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.813 |
Cdk9 | CycH | FBpp0071848 | FBpp0078093 | Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control. | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | 0.993 |
Cdk9 | CycK | FBpp0071848 | FBpp0310472 | Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control. | Cyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by RpII215) and contributes to pre-mRNA processing, transcription and chromatin structure. | 0.999 |
Cdk9 | RpII215 | FBpp0071848 | FBpp0073387 | Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control. | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | 0.972 |
Cdk9 | Spt5 | FBpp0071848 | FBpp0085716 | Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control. | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development; Belongs [...] | 0.997 |
CycH | Cdk12 | FBpp0078093 | FBpp0078014 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.932 |
CycH | Cdk9 | FBpp0078093 | FBpp0071848 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control. | 0.993 |
CycH | CycK | FBpp0078093 | FBpp0310472 | Cyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. | Cyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by RpII215) and contributes to pre-mRNA processing, transcription and chromatin structure. | 0.970 |