node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG31855 | CG6325 | FBpp0288439 | FBpp0081737 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | LD10232p; It is involved in the biological process described with: protein ubiquitination. | 0.540 |
CG31855 | CG9945 | FBpp0288439 | FBpp0085539 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. | 0.638 |
CG31855 | CSN3 | FBpp0288439 | FBpp0077927 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes [...] | 0.451 |
CG31855 | CSN6 | FBpp0288439 | FBpp0083658 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes [...] | 0.490 |
CG31855 | Cul4 | FBpp0288439 | FBpp0290569 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome; Belongs to the cullin family. | 0.949 |
CG31855 | DCAF12 | FBpp0288439 | FBpp0307414 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | DDB1 and CUL4 associated factor 12, isoform A; It is involved in the biological process described with: regulation of programmed cell death; salivary gland cell autophagic cell death. | 0.544 |
CG31855 | Roc1a | FBpp0288439 | FBpp0300874 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | RING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] | 0.605 |
CG31855 | alien | FBpp0288439 | FBpp0308633 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | COP9 signalosome complex subunit 2; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes [...] | 0.408 |
CG31855 | pic | FBpp0288439 | FBpp0082177 | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | Piccolo (pic) encodes the Ddb1 protein, which functions to recruit substrate receptors to Cul4-based E3 ubiquitin ligase complexes, which catalyze the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome. | 0.993 |
CG6325 | CG31855 | FBpp0081737 | FBpp0288439 | LD10232p; It is involved in the biological process described with: protein ubiquitination. | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | 0.540 |
CG6325 | CG9945 | FBpp0081737 | FBpp0085539 | LD10232p; It is involved in the biological process described with: protein ubiquitination. | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. | 0.649 |
CG6325 | Cul4 | FBpp0081737 | FBpp0290569 | LD10232p; It is involved in the biological process described with: protein ubiquitination. | Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome; Belongs to the cullin family. | 0.547 |
CG6325 | DCAF12 | FBpp0081737 | FBpp0307414 | LD10232p; It is involved in the biological process described with: protein ubiquitination. | DDB1 and CUL4 associated factor 12, isoform A; It is involved in the biological process described with: regulation of programmed cell death; salivary gland cell autophagic cell death. | 0.540 |
CG6325 | Roc1a | FBpp0081737 | FBpp0300874 | LD10232p; It is involved in the biological process described with: protein ubiquitination. | RING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] | 0.540 |
CG9945 | CG31855 | FBpp0085539 | FBpp0288439 | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. | RE70574p; It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | 0.638 |
CG9945 | CG6325 | FBpp0085539 | FBpp0081737 | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. | LD10232p; It is involved in the biological process described with: protein ubiquitination. | 0.649 |
CG9945 | CSN3 | FBpp0085539 | FBpp0077927 | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes [...] | 0.705 |
CG9945 | CSN6 | FBpp0085539 | FBpp0083658 | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes [...] | 0.778 |
CG9945 | Cul4 | FBpp0085539 | FBpp0290569 | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. | Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome; Belongs to the cullin family. | 0.936 |
CG9945 | DCAF12 | FBpp0085539 | FBpp0307414 | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. | DDB1 and CUL4 associated factor 12, isoform A; It is involved in the biological process described with: regulation of programmed cell death; salivary gland cell autophagic cell death. | 0.694 |