STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Mgat1Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1) encodes an enzyme involved in the synthesis of paucimannose N-glycans. It is required in the CNS, with involvement in locomotion, brain development and lifespan. (458 aa)    
Predicted Functional Partners:
alpha-Man-IIa
Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).
   
 
 0.977
Mgat2
Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat2) encodes an enzyme involved in protein N-linked glycosylation.
      
 0.939
alpha-Man-Ia
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
   
 0.939
alpha-Man-Ic
alpha-1,2-Mannosidase; Calcium ion binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. It is involved in the biological process described with: N-glycan processing; Belongs to the glycosyl hydrolase 47 family.
    
 0.935
fdl
Probable beta-hexosaminidase fdl; Involved in brain restructurization via hormonal control during metamorphosis. Implicated in N-glycan processing. Belongs to the glycosyl hydrolase 20 family.
   
  
 0.870
FucTD
Alpha-(1->3)-fucosyltransferase activity. It is involved in the biological process described with: fucosylation; protein glycosylation.
      
 0.847
Mgat3
LD34806p; Transferase activity, transferring glycosyl groups; beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: protein N-linked glycosylation; N-acetylglucosamine metabolic process.
      
 0.846
FucTC
Fucosyltransferase activity; alpha-(1->3)-fucosyltransferase activity. It is involved in the biological process described with: fucosylation; protein glycosylation; Belongs to the glycosyltransferase 10 family.
      
 0.842
beta4GalNAcTA
beta1,4-N-acetylgalactosaminyltransferase A (beta4GalNAcTA) encodes a acetylgalactosaminyltransferase involved in glycolipid biosynthesis. It contributes to the development of the neuromuscular junction.
   
  
 0.771
FucTA
Glycoprotein 3-alpha-L-fucosyltransferase A; Alpha1,3-fucosyltransferase A (FucTA) encodes a Golgi fucosyltransferase that transfers fucose in alpha1,3-linkage to core N-acetylglucosamine residues of N-linked oligosaccharides. It is required for the synthesis of the anti-horseradish peroxidase epitope; Belongs to the glycosyltransferase 10 family.
   
  
 0.722
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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