node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BNIP3 | CG12511 | FBpp0077874 | FBpp0292075 | RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process. | Uncharacterized protein, isoform B; It is involved in the biological process described with: autophagy of mitochondrion. | 0.829 |
BNIP3 | CG5676 | FBpp0077874 | FBpp0079675 | RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process. | RE45833p; It is involved in the biological process described with: autophagy of mitochondrion. | 0.830 |
BNIP3 | raptor | FBpp0077874 | FBpp0311819 | RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process. | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. | 0.501 |
BNIP3 | zda | FBpp0077874 | FBpp0311548 | RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process. | Peptidylprolyl isomerase; Zonda (zda) encodes an immunophillin of the FKBP family that localizes at the endosomal reticulum. It physically interacts with the products of Atg1 and Pi3K59F and is required for omegasome biogenesis and for starvation-induced autophagy. | 0.673 |
CG12511 | BNIP3 | FBpp0292075 | FBpp0077874 | Uncharacterized protein, isoform B; It is involved in the biological process described with: autophagy of mitochondrion. | RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process. | 0.829 |
CG12511 | CG5676 | FBpp0292075 | FBpp0079675 | Uncharacterized protein, isoform B; It is involved in the biological process described with: autophagy of mitochondrion. | RE45833p; It is involved in the biological process described with: autophagy of mitochondrion. | 0.900 |
CG12511 | zda | FBpp0292075 | FBpp0311548 | Uncharacterized protein, isoform B; It is involved in the biological process described with: autophagy of mitochondrion. | Peptidylprolyl isomerase; Zonda (zda) encodes an immunophillin of the FKBP family that localizes at the endosomal reticulum. It physically interacts with the products of Atg1 and Pi3K59F and is required for omegasome biogenesis and for starvation-induced autophagy. | 0.700 |
CG1847 | Hsp83 | FBpp0303439 | FBpp0305095 | Uncharacterized protein, isoform C. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.920 |
CG1847 | zda | FBpp0303439 | FBpp0311548 | Uncharacterized protein, isoform C. | Peptidylprolyl isomerase; Zonda (zda) encodes an immunophillin of the FKBP family that localizes at the endosomal reticulum. It physically interacts with the products of Atg1 and Pi3K59F and is required for omegasome biogenesis and for starvation-induced autophagy. | 0.844 |
CG5676 | BNIP3 | FBpp0079675 | FBpp0077874 | RE45833p; It is involved in the biological process described with: autophagy of mitochondrion. | RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process. | 0.830 |
CG5676 | CG12511 | FBpp0079675 | FBpp0292075 | RE45833p; It is involved in the biological process described with: autophagy of mitochondrion. | Uncharacterized protein, isoform B; It is involved in the biological process described with: autophagy of mitochondrion. | 0.900 |
CG5676 | zda | FBpp0079675 | FBpp0311548 | RE45833p; It is involved in the biological process described with: autophagy of mitochondrion. | Peptidylprolyl isomerase; Zonda (zda) encodes an immunophillin of the FKBP family that localizes at the endosomal reticulum. It physically interacts with the products of Atg1 and Pi3K59F and is required for omegasome biogenesis and for starvation-induced autophagy. | 0.703 |
Hsp83 | CG1847 | FBpp0305095 | FBpp0303439 | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | Uncharacterized protein, isoform C. | 0.920 |
Hsp83 | Tor | FBpp0305095 | FBpp0307598 | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] | 0.911 |
Hsp83 | zda | FBpp0305095 | FBpp0311548 | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | Peptidylprolyl isomerase; Zonda (zda) encodes an immunophillin of the FKBP family that localizes at the endosomal reticulum. It physically interacts with the products of Atg1 and Pi3K59F and is required for omegasome biogenesis and for starvation-induced autophagy. | 0.634 |
Lst8 | PRAS40 | FBpp0071303 | FBpp0312548 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Proline-rich Akt substrate 40 kDa (PRAS40) encodes a protein that functions to link Insulin/IGF signaling and the activation of the product of Tor in a tissue-specific manner, affecting the activity of the product of Tor in the ovary but not in other fly tissues. | 0.998 |
Lst8 | Tor | FBpp0071303 | FBpp0307598 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] | 0.999 |
Lst8 | raptor | FBpp0071303 | FBpp0311819 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. | 0.999 |
Lst8 | zda | FBpp0071303 | FBpp0311548 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Peptidylprolyl isomerase; Zonda (zda) encodes an immunophillin of the FKBP family that localizes at the endosomal reticulum. It physically interacts with the products of Atg1 and Pi3K59F and is required for omegasome biogenesis and for starvation-induced autophagy. | 0.705 |
PRAS40 | Lst8 | FBpp0312548 | FBpp0071303 | Proline-rich Akt substrate 40 kDa (PRAS40) encodes a protein that functions to link Insulin/IGF signaling and the activation of the product of Tor in a tissue-specific manner, affecting the activity of the product of Tor in the ovary but not in other fly tissues. | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | 0.998 |