node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCT2 | Cka | FBpp0071226 | FBpp0297142 | Chaperonin containing TCP1 subunit 2; ATP binding; unfolded protein binding. It is involved in the biological process described with: protein folding. | Connector of kinase to AP-1, isoform E; Protein binding. | 0.796 |
CCT2 | GckIII | FBpp0071226 | FBpp0082840 | Chaperonin containing TCP1 subunit 2; ATP binding; unfolded protein binding. It is involved in the biological process described with: protein folding. | Germinal centre kinase III (GckIII) encodes a serine/threonine kinase of the STE20 superfamily. It is the sole Drosophila germinal center kinase type 3 family member. Loss of GckIIII results in tube dilation defects that are specific to the terminal cells of the tracheal system. | 0.773 |
CCT2 | Mob4 | FBpp0071226 | FBpp0297918 | Chaperonin containing TCP1 subunit 2; ATP binding; unfolded protein binding. It is involved in the biological process described with: protein folding. | MOB kinase activator 4 (Mob4) encodes a protein that contributes to microtubule organization, axonal transport, mitotic spindle assembly and regulation of Hippo signaling; Belongs to the MOB1/phocein family. | 0.876 |
CCT2 | Naus | FBpp0071226 | FBpp0311543 | Chaperonin containing TCP1 subunit 2; ATP binding; unfolded protein binding. It is involved in the biological process described with: protein folding. | Uncharacterized protein CG10915; It is involved in the biological process described with: regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of neuron projection arborization; positive regulation of lamellipodium morphogenesis; actin filament bundle retrograde transport; protein localization to actin cytoskeleton. | 0.872 |
CCT2 | mts | FBpp0071226 | FBpp0310062 | Chaperonin containing TCP1 subunit 2; ATP binding; unfolded protein binding. It is involved in the biological process described with: protein folding. | Serine/threonine-protein phosphatase PP2A; Microtubule star (mts) encodes the catalytic subunit of protein phosphatase 2A. It is involved in various developmental processes and signaling pathways, such as Hh signaling and Wingless signaling; Belongs to the PPP phosphatase family. PP-2A subfamily. | 0.883 |
Ccm3 | Cka | FBpp0082550 | FBpp0297142 | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | Connector of kinase to AP-1, isoform E; Protein binding. | 0.993 |
Ccm3 | Fgop2 | FBpp0082550 | FBpp0304603 | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | FGFR1 oncogene partner 2 homolog; It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction; Belongs to the SIKE family. | 0.996 |
Ccm3 | GckIII | FBpp0082550 | FBpp0082840 | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | Germinal centre kinase III (GckIII) encodes a serine/threonine kinase of the STE20 superfamily. It is the sole Drosophila germinal center kinase type 3 family member. Loss of GckIIII results in tube dilation defects that are specific to the terminal cells of the tracheal system. | 0.998 |
Ccm3 | Mob4 | FBpp0082550 | FBpp0297918 | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | MOB kinase activator 4 (Mob4) encodes a protein that contributes to microtubule organization, axonal transport, mitotic spindle assembly and regulation of Hippo signaling; Belongs to the MOB1/phocein family. | 0.998 |
Ccm3 | Naus | FBpp0082550 | FBpp0311543 | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | Uncharacterized protein CG10915; It is involved in the biological process described with: regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of neuron projection arborization; positive regulation of lamellipodium morphogenesis; actin filament bundle retrograde transport; protein localization to actin cytoskeleton. | 0.996 |
Ccm3 | Pp2A-29B | FBpp0082550 | FBpp0308836 | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit; Protein phosphatase 2A at 29B (Pp2A-29B) encodes the structural A subunit of the trimeric PP2A phosphatase enzyme. It links the catalytic C subunit encoded by mts and a variable regulatory B family subunit, which directs the enzyme to distinct substrates. The roles of Pp2A-29B product include centriole duplication, chromosome segregation, autophagy, axonal transport, growth regulation, and active zone stabilization. | 0.994 |
Ccm3 | Slmap | FBpp0082550 | FBpp0110594 | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | Sarcolemma associated protein, isoform A; Protein kinase binding. It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction. | 0.938 |
Ccm3 | Strip | FBpp0082550 | FBpp0072946 | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | Striatin interacting protein, isoform B; Striatin interacting protein (Strip) encodes an intracellular protein and component of the STRIPAK PP2A protein complex. It is involved in Hippo signaling, endosome maturation, and microtubule regulation. | 0.995 |
Ccm3 | mts | FBpp0082550 | FBpp0310062 | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | Serine/threonine-protein phosphatase PP2A; Microtubule star (mts) encodes the catalytic subunit of protein phosphatase 2A. It is involved in various developmental processes and signaling pathways, such as Hh signaling and Wingless signaling; Belongs to the PPP phosphatase family. PP-2A subfamily. | 0.989 |
Cka | CCT2 | FBpp0297142 | FBpp0071226 | Connector of kinase to AP-1, isoform E; Protein binding. | Chaperonin containing TCP1 subunit 2; ATP binding; unfolded protein binding. It is involved in the biological process described with: protein folding. | 0.796 |
Cka | Ccm3 | FBpp0297142 | FBpp0082550 | Connector of kinase to AP-1, isoform E; Protein binding. | Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation. | 0.993 |
Cka | Fgop2 | FBpp0297142 | FBpp0304603 | Connector of kinase to AP-1, isoform E; Protein binding. | FGFR1 oncogene partner 2 homolog; It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction; Belongs to the SIKE family. | 0.998 |
Cka | GckIII | FBpp0297142 | FBpp0082840 | Connector of kinase to AP-1, isoform E; Protein binding. | Germinal centre kinase III (GckIII) encodes a serine/threonine kinase of the STE20 superfamily. It is the sole Drosophila germinal center kinase type 3 family member. Loss of GckIIII results in tube dilation defects that are specific to the terminal cells of the tracheal system. | 0.985 |
Cka | Mob4 | FBpp0297142 | FBpp0297918 | Connector of kinase to AP-1, isoform E; Protein binding. | MOB kinase activator 4 (Mob4) encodes a protein that contributes to microtubule organization, axonal transport, mitotic spindle assembly and regulation of Hippo signaling; Belongs to the MOB1/phocein family. | 0.996 |
Cka | Naus | FBpp0297142 | FBpp0311543 | Connector of kinase to AP-1, isoform E; Protein binding. | Uncharacterized protein CG10915; It is involved in the biological process described with: regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of neuron projection arborization; positive regulation of lamellipodium morphogenesis; actin filament bundle retrograde transport; protein localization to actin cytoskeleton. | 0.995 |