STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
APC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC10 family. (195 aa)    
Predicted Functional Partners:
APC7
Anaphase Promoting Complex subunit 7 (APC7) encodes a protein that associates with the anaphase promoting complex/cyclosome (APC/C). It shows synergistic genetic interaction with the essential APC/C subunit encoded by Cdc23. The association of the product of APC7 and APC/C may be either transient or occurs only in certain forms of the APC/C complex.
   
 0.999
APC4
Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.
   
 0.999
ida
Imaginal discs arrested (ida) encodes a ubiquitin ligase that regulates the mitotic metaphase/anaphase transition.
   
 0.999
Cdc16
Cell division cycle 16 (Cdc16) encodes an essential subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding.
   
 0.999
CG33981
Uncharacterized protein, isoform C; It is involved in the biological process described with: protein K11-linked ubiquitination.
    
 0.999
Cdc27
Cell division cycle 27 (Cdc27) encodes a component of the anaphase-promoting complex/cyclosome (APC/C). It is important for substrate recruitment and interacts with its co-activators, encoded by fzy and fzr, as well as the mitotic checkpoint proteins, encoded by mad2 and BubR1.
   
 0.999
mr
Morula (mr) encodes the APC2 subunit of the anaphase promoting complex (APC). mr strong alleles produce lethality, metaphase arrest and neuroblast polyploidy. mr weak alleles result in female sterility, affecting the endocycle in the nurse cells, as well as metaphase arrest in early embryonic mitoses; Belongs to the cullin family.
    
 0.998
shtd
Shattered (shtd) encodes the largest subunit that forms the scaffold of the Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligase. APC/C is active during mitosis and G1 phases of the cell cycle to mediates the degradation of cyclins and other key cell cycle regulators, which triggers the metaphase to anaphase transition and the exit from mitosis.
    
 0.998
Cdc23
Cell division cycle 23 (Cdc23) encodes a subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding.
   
 0.998
CG15237
GEO10730p1; It is involved in the biological process described with: regulation of mitotic cell cycle spindle assembly checkpoint.
   
 0.997
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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