STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cbp53ECalbindin-32; Calcium ion binding. It is involved in the biological process described with: cellular calcium ion homeostasis (310 aa)    
Predicted Functional Partners:
ple
Pale is a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development
   
  
 0.799
CaMKI
Calmodulin-dependent protein kinase activity; ATP binding; calmodulin binding; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation
   
 
 0.797
toy
Twin of eyeless, isoform A; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with: positive regulation of transcription from RNA polymerase II promoter; brain morphogenesis; ocellus development; compound eye development; positive regulation of gene expression; eye-antennal disc development; regulation of transcription, DNA-templated; mushroom body development
   
 
 0.696
PMCA
Plasma membrane calcium ATPase (PMCA) is a P-type ion pump found in the plasma membrane; PMCA functiones as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction PMCA plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx
   
 
 0.685
ey
Paired box protein Pax-6; Involved in eye morphogenesis
   
 
 0.661
Gad1
Glutamate decarboxylase; Catalyzes the production of GABA; Belongs to the group II decarboxylase family
   
 
 0.660
Nmdar1
Glutamate [NMDA] receptor subunit 1; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation
   
 
 0.652
Rdl
Gamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin is a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior
   
  
 0.629
Cam
Calmodulin is a Calcium-binding messenger protein. It acts as a part of the calcium signal transduction pathway and interacts with various target proteins such as kinases or phosphatases. It is involved in actin filament-based movement, mitotic spinde assembly, axon guidance, DNA damage response, autophagy, cell death, sensory perception, and muscle homeostasis
      
 0.609
Cha
Choline acetyltransferase (ChAT) catalyzes the biosynthesis of the neurotransmitter acetylcholine. ChAT is considered to be a specific marker for cholinergic neurons
   
  
 0.604
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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