STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
JheCarboxylic ester hydrolase; Juvenile hormone esterase (Jhe) encodes a juvenile-hormone esterase involved in response to ethanol, juvenile hormone catabolism and male mating behavior; Belongs to the type-B carboxylesterase/lipase family. (579 aa)    
Predicted Functional Partners:
Jheh1
Juvenile hormone epoxide hydrolase 1 (Jheh1) expression changes are associated with increased tolerance to oxidative stress; Belongs to the peptidase S33 family.
   
 0.990
Jheh3
Epoxide hydrolase; Catalyzes juvenile hormone hydrolysis. Belongs to the peptidase S33 family.
    
 0.989
Jheh2
Juvenile hormone epoxide hydrolase 2 (Jheh2) encodes an enzyme that hydrolyzes cis-stilbene oxide. Jheh2 expression changes are associated with increased tolerance to oxidative stress; Belongs to the peptidase S33 family.
   
 0.988
jhamt
Juvenile hormone acid O-methyltransferase; O-methyltransferase that transfers a methyl group from S- adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis. Also able to methylate farnesoate to methyl farnesoate.
      
 0.910
CG3776
LD24657p; Ribosome binding; protein binding. It is involved in the biological process described with: inner mitochondrial membrane organization; protein insertion into mitochondrial inner membrane from matrix.
    
 
 0.744
CG8757
Uncharacterized protein; 3-keto sterol reductase activity; 17-beta-ketosteroid reductase activity; estradiol 17-beta-dehydrogenase activity; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.666
CG3301
GH01837p; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 3-keto sterol reductase activity; 17-beta-ketosteroid reductase activity; estradiol 17-beta-dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.661
CG40485
RH03309p; Estradiol 17-beta-dehydrogenase activity; 17-beta-ketosteroid reductase activity; 3-keto sterol reductase activity; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.660
CG40486
MIP01391p; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; estradiol 17-beta-dehydrogenase activity; 3-keto sterol reductase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.660
Kr-h1
Kruppel homolog 1 (Kr-h1) encodes a transcriptional regulator involved in axon pathfinding, neurite and axon remodeling as well as pupal photoreceptor maturation. In all cases, the function of the product of Kr-h1 is linked to that of the 20-hydroxyecdysone hormone.
    
 
 0.608
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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