STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG8388IP14661p; Zinc ion binding; DNA-binding transcription factor activity; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of gene expression; regulation of transcription, DNA-templated. (572 aa)    
Predicted Functional Partners:
CG4707
LD29879p; Transcription regulatory region sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of gene expression; regulation of transcription, DNA-templated.
  
 
 
0.796
Caf1-55
Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...]
    
 0.565
Chd3
Chromodomain-helicase-DNA-binding protein 3; Chd3 (Chd3) encodes a nuclear ATP-dependent nucleosome remodeler of the CHD family. It associates with active chromatin and utilizes the energy of ATP hydrolysis to move nucleosomes along DNA.
   
 0.546
Mi-2
Chromodomain-helicase-DNA-binding protein Mi-2 homolog; Mi-2 (Mi-2) encodes a nuclear ATP-dependent nucleosome remodeler of the CHD family. It associates with active chromatin and utilizes the energy of ATP hydrolysis to move nucleosomes along DNA. It is required for repression of cell type-specific genes, full activation of heat shock genes and regulates higher order chromatin structure of polytene chromosomes.
   
 0.543
Su(var)3-3
Possible lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for heterochromatic gene silencing. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and tri-methylated 'Lys-4' of histone H3. May also demethylate 'Lys-9' of histone H3, Plays a role in the repression of neuronal genes; Belongs to the flavin monoamine oxidase family.
   
  0.533
HDAC1
Histone deacetylase HDAC1; Catalyzes the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcript [...]
    
  0.531
Hmg-2
High mobility group protein 2 (Hmg-2) encodes a member of the non-histone chromosomal high-mobility group protein family. These proteins associate with with chromatin and are ubiquitously distributed in the nucleus of eukaryotic cells. The product of Hmg-2 binds to DNA in a non-sequence specific fashion to induce structural changes in DNA that include bending and unwinding that in turn, promote DNA flexibility.
   
  0.530
CoRest
CoRest, isoform G; CoRest (CoRest) encodes a DNA binding factor that controls transcription in cooperation with other transcriptional regulators. It positively modulates Notch signaling as well as showing co-repressor activity via histone modification regulation.
    
  0.529
simj
Simjang, isoform E; Simjang (simj) encodes a component of the NURD complex, which couples chromatin remodelling and histone deacetylation to mediate transcriptional repression. The product of simj is involded in cardiogenesis and habituation.
    
  0.529
CG10366
Uncharacterized protein; DNA binding; zinc ion binding. It is involved in the biological process described with: regulation of gene expression.
  
 
 
0.523
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.