STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG8204FI21960p1; It is involved in the biological process described with: snoRNA localization; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); box C/D snoRNP assembly. (143 aa)    
Predicted Functional Partners:
fs(1)K10
DNA-binding protein K10; Female sterile (1) K10 (fs(1)K10) encodes a nuclear protein of unknown biochemical function required during oogenesis for the proper localization of grk mRNA and protein in the oocyte, a key step in the specification of the dorsoventral axis of the oocyte, mature egg, and future embryo.
    
 
 0.956
Nufip
Nufip (Nufip) encodes an adaptor protein for the assembly of RiboNucleo-Particles (RNPs) such as the small nuclear RNP U4 (snRNP U4; part of the spliceosome) and the mRNPs encoding seleno-proteins. It is necessary for the biogenesis of the small nucleolar RNPs (snoRNPs).
    
 
 0.896
CG1463
RE61595p; It is involved in the biological process described with: box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); snoRNA localization.
    
 0.835
Pih1D1
PIH1 domain containing 1, isoform D.
   
  
 0.543
CG18596
LP02352p; RNA binding; tRNA (guanine) methyltransferase activity. It is involved in the biological process described with: tRNA methylation.
      
 0.530
CG31223
LD44220p.
      
 0.528
Ada2b
Transcriptional adapter 2B; Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.
    
 
 0.518
CG3295
GH10162p; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process.
      
 0.440
CG16908
Uncharacterized protein; It is involved in the biological process described with: regulation of TOR signaling.
      
 0.438
spag
FI17138p1; Spaghetti (spag) encodes a TPR domain-containing co-chaperone that associates with Hsp70 and Hsp90 to regulate their activity in macromolecular complexes like RNA polymerase, ribonucleoproteins and Phosphatidyl-Inositol 3-kinase-related kinases. It has been shown to regulate the product of dco levels, with consequences for circadian rhythms and apoptosis.
      
 0.435
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.