node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG42709 | Cirl | FBpp0292106 | FBpp0302596 | LD45603p. | Latrophilin Cirl; Latrotoxin receptor activity; G protein-coupled receptor activity; carbohydrate binding; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | 0.871 |
CG42709 | unc-5 | FBpp0292106 | FBpp0309017 | LD45603p. | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. | 0.912 |
CG6867 | unc-5 | FBpp0088539 | FBpp0309017 | FI21454p1; It is involved in the biological process described with: motor neuron axon guidance; synaptic target inhibition. | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. | 0.834 |
Cirl | CG42709 | FBpp0302596 | FBpp0292106 | Latrophilin Cirl; Latrotoxin receptor activity; G protein-coupled receptor activity; carbohydrate binding; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | LD45603p. | 0.871 |
Cirl | sli | FBpp0302596 | FBpp0303578 | Latrophilin Cirl; Latrotoxin receptor activity; G protein-coupled receptor activity; carbohydrate binding; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Slit (sli) encodes a secreted glycoprotein that acts as a ligand for the Robo receptor family and co-receptors, including the products of Sdc and Dscam1. The product of sli functions as second messenger (via Abl) and receptor dependent, providing repellent (neural growth cone), attractive (trachea), and polarising (cardioblasts) cues for differentiating cells. | 0.715 |
Cirl | unc-5 | FBpp0302596 | FBpp0309017 | Latrophilin Cirl; Latrotoxin receptor activity; G protein-coupled receptor activity; carbohydrate binding; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. | 0.994 |
Dscam1 | NetA | FBpp0297683 | FBpp0311922 | Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. | Netrin-A; Netrins control guidance of CNS commissural axons at the midline and peripheral motor axons to their target muscles. | 0.521 |
Dscam1 | NetB | FBpp0297683 | FBpp0291228 | Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. | Netrin-B; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively. While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5. | 0.844 |
Dscam1 | fra | FBpp0297683 | FBpp0086935 | Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. | Frazzled, isoform A; Frazzled (fra) encodes a DCC-like Netrin receptor that mediates axon guidance. It also contributes to dendrite guidance, development and morphogenesis. | 0.449 |
Dscam1 | sli | FBpp0297683 | FBpp0303578 | Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. | Slit (sli) encodes a secreted glycoprotein that acts as a ligand for the Robo receptor family and co-receptors, including the products of Sdc and Dscam1. The product of sli functions as second messenger (via Abl) and receptor dependent, providing repellent (neural growth cone), attractive (trachea), and polarising (cardioblasts) cues for differentiating cells. | 0.738 |
Dscam1 | unc-5 | FBpp0297683 | FBpp0309017 | Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. | 0.817 |
NetA | Dscam1 | FBpp0311922 | FBpp0297683 | Netrin-A; Netrins control guidance of CNS commissural axons at the midline and peripheral motor axons to their target muscles. | Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. | 0.521 |
NetA | fra | FBpp0311922 | FBpp0086935 | Netrin-A; Netrins control guidance of CNS commissural axons at the midline and peripheral motor axons to their target muscles. | Frazzled, isoform A; Frazzled (fra) encodes a DCC-like Netrin receptor that mediates axon guidance. It also contributes to dendrite guidance, development and morphogenesis. | 0.674 |
NetA | unc-5 | FBpp0311922 | FBpp0309017 | Netrin-A; Netrins control guidance of CNS commissural axons at the midline and peripheral motor axons to their target muscles. | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. | 0.942 |
NetB | Dscam1 | FBpp0291228 | FBpp0297683 | Netrin-B; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively. While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5. | Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. | 0.844 |
NetB | fra | FBpp0291228 | FBpp0086935 | Netrin-B; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively. While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5. | Frazzled, isoform A; Frazzled (fra) encodes a DCC-like Netrin receptor that mediates axon guidance. It also contributes to dendrite guidance, development and morphogenesis. | 0.962 |
NetB | sli | FBpp0291228 | FBpp0303578 | Netrin-B; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively. While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5. | Slit (sli) encodes a secreted glycoprotein that acts as a ligand for the Robo receptor family and co-receptors, including the products of Sdc and Dscam1. The product of sli functions as second messenger (via Abl) and receptor dependent, providing repellent (neural growth cone), attractive (trachea), and polarising (cardioblasts) cues for differentiating cells. | 0.786 |
NetB | trio | FBpp0291228 | FBpp0072540 | Netrin-B; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively. While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5. | Trio, isoform A; Trio (trio) encodes a Rho guanine nucleotide exchange factor (GEF) that activates the Rho-family GTPases to regulate actin structure and cell adhesion. The GEF encoded by trio acts in several signaling pathways, including Abl tyrosine kinase and BMP signaling pathways. The product of trio is involved in neural wiring (axon and dendrite patterning and synaptogenesis) and muscle development. | 0.413 |
NetB | unc-5 | FBpp0291228 | FBpp0309017 | Netrin-B; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively. While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5. | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. | 0.950 |
dally | unc-5 | FBpp0297069 | FBpp0309017 | Division abnormally delayed (dally) encodes a core protein of heparan sulfate proteoglycans of the glypican family. It acts as a co-receptor for growth factors and morphogens, such as the products of dpp, wg, hh, upd1 and FGFs, affecting signaling and distribution of these ligands. The roles of the product of dally include wing development and germline stem cell maintenance. | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. | 0.880 |