STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp6a8Cytochrome P450 6a8; Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (506 aa)    
Predicted Functional Partners:
Cpr
NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). May function to clear the olfactory organ (antennae) from accumulating chemicals. In the N-terminal section; belongs to the flavodoxin family.
 
 
 
 0.915
CG13667
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family.
 
  
 
 0.903
CG2065
RH23455p; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.658
Jheh1
Juvenile hormone epoxide hydrolase 1 (Jheh1) expression changes are associated with increased tolerance to oxidative stress; Belongs to the peptidase S33 family.
  
 
 0.593
CG6908
Uncharacterized protein, isoform A; It is involved in the biological process described with: copper ion homeostasis.
   
  
 0.586
CG14882
Uncharacterized protein, isoform A; [methionine synthase] reductase activity. It is involved in the biological process described with: oxidation-reduction process; methionine biosynthetic process.
 
  
 
 0.564
Cyp4e2
Cytochrome P450 4e2; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.563
Cyp6w1
Probable cytochrome P450 6w1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
  
0.557
GstD2
Glutathione S-transferase D2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May be involved in detoxification.
   
  
 0.546
Cyp12d1-p
Probable cytochrome P450 12d1 proximal, mitochondrial; Cyp12d1-p (Cyp12d1-p) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).
  
 
0.546
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: medium (78%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.