STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMC2Structural maintenance of chromosomes 2 (SMC2) encodes a condensin subunit involved in chromosome condensation and cell division. It contributes to neurogenesis and stem cell differentiation. (1179 aa)    
Predicted Functional Partners:
glu
Structural maintenance of chromosomes protein; Gluon (glu) encodes a subunit of the multiprotein complex condensin that is required for chromosome condensation and sister chromatid segregation. It contributes to nervous system development and glucose metabolism.
   
0.999
Cap-D2
Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
   
 0.999
Cap-G
Chromosome associated protein G (Cap-G) encodes a component of the condensin I complex, necessary for accurate mitotic and meiotic chromosome segregation.
   
 0.999
barr
Condensin complex subunit 2; Barren (barr) encodes a chromatin binding protein involved in chromatin condensation. It regulates Malpighian tubule development and epithelial morphogenesis.
   
 0.999
Cap-H2
Chromosome associated protein H2 (Cap-H2) encodes a condensin protein involved in chromatin organization and chromosome segregation.
   
 0.998
Cap-D3
Condensin-2 complex subunit; Chromatin binding; histone binding; methylated histone binding.
   
 0.997
Top2
DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. During meiosis, it disrupts heterochromatic connections between achiasmate and chiasmate homologs after spindle assembly so that chromosomes can separate at prometaphase I. During mitosis, it functions in the separation of sister chromatids by establishing amphitelic kinetochore attachments in mitotic spindles. May have a role in chromatin [...]
   
 
 0.975
Klp61F
Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...]
   
 
 0.959
Ndc80
LD33040p; Ndc80 (Ndc80) encodes a protein involved in mitotic metaphase plate congression.
   
 
 0.952
elg1
Enhanced level of genomic instability 1, isoform C; DNA binding; DNA clamp unloader activity. It is involved in the biological process described with: oogenesis.
   
 
 0.904
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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