node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akt1 | Lst8 | FBpp0082682 | FBpp0071303 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | 0.759 |
Akt1 | PRAS40 | FBpp0082682 | FBpp0312548 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Proline-rich Akt substrate 40 kDa (PRAS40) encodes a protein that functions to link Insulin/IGF signaling and the activation of the product of Tor in a tissue-specific manner, affecting the activity of the product of Tor in the ovary but not in other fly tissues. | 0.979 |
Akt1 | Rheb | FBpp0082682 | FBpp0078342 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | GTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K through activation of TORC1 signaling. May also have a role in activating TORC2 signaling. | 0.957 |
Akt1 | S6k | FBpp0082682 | FBpp0305462 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. | 0.908 |
Akt1 | Sin1 | FBpp0082682 | FBpp0086616 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Stress-activated map kinase-interacting protein 1; Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. | 0.876 |
Akt1 | Tor | FBpp0082682 | FBpp0307598 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] | 0.984 |
Akt1 | gig | FBpp0082682 | FBpp0074588 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Gigas, isoform A; Gigas (gig) encodes a tumour suppressor protein that, together with with the product of Tsc1, controls cellular growth via antagonizing insulin and TOR signalling pathways. | 0.995 |
Akt1 | nonC | FBpp0082682 | FBpp0309979 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Serine/threonine-protein kinase Smg1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1. | 0.555 |
Akt1 | raptor | FBpp0082682 | FBpp0311819 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. | 0.996 |
Akt1 | rictor | FBpp0082682 | FBpp0074458 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Rapamycin-insensitive companion of Tor (rictor) encodes an essential component of TOR complex 2 where it controls phosphorylation of protein kinases, such as those encoded by Akt1 and trc. The product of rictor contributes to the regulation of tissue growth, dendritic tiling, long term memory, tolerance to heat stress, and mitochondrial quality control. | 0.986 |
Lst8 | Akt1 | FBpp0071303 | FBpp0082682 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | 0.759 |
Lst8 | PRAS40 | FBpp0071303 | FBpp0312548 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Proline-rich Akt substrate 40 kDa (PRAS40) encodes a protein that functions to link Insulin/IGF signaling and the activation of the product of Tor in a tissue-specific manner, affecting the activity of the product of Tor in the ovary but not in other fly tissues. | 0.998 |
Lst8 | Rheb | FBpp0071303 | FBpp0078342 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | GTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K through activation of TORC1 signaling. May also have a role in activating TORC2 signaling. | 0.993 |
Lst8 | S6k | FBpp0071303 | FBpp0305462 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. | 0.985 |
Lst8 | Sin1 | FBpp0071303 | FBpp0086616 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Stress-activated map kinase-interacting protein 1; Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. | 0.999 |
Lst8 | Tor | FBpp0071303 | FBpp0307598 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] | 0.999 |
Lst8 | gig | FBpp0071303 | FBpp0074588 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Gigas, isoform A; Gigas (gig) encodes a tumour suppressor protein that, together with with the product of Tsc1, controls cellular growth via antagonizing insulin and TOR signalling pathways. | 0.876 |
Lst8 | nonC | FBpp0071303 | FBpp0309979 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Serine/threonine-protein kinase Smg1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1. | 0.933 |
Lst8 | raptor | FBpp0071303 | FBpp0311819 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. | 0.999 |
Lst8 | rictor | FBpp0071303 | FBpp0074458 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. | Rapamycin-insensitive companion of Tor (rictor) encodes an essential component of TOR complex 2 where it controls phosphorylation of protein kinases, such as those encoded by Akt1 and trc. The product of rictor contributes to the regulation of tissue growth, dendritic tiling, long term memory, tolerance to heat stress, and mitochondrial quality control. | 0.999 |