node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cenp-C | His2A:CG31618 | FBpp0088911 | FBpp0085249 | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.664 |
Cenp-C | cal1 | FBpp0088911 | FBpp0082841 | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | Chromosome alignment defect 1 (cal1) encodes a protein that is required for maintenance of the epigenetic marks specifying centromeres. It binds to newly synthesized centromere-specific histone H3 variant encoded by cid and recruits it to the centromere by binding to the centromere protein encoded by Cenp-C. | 0.998 |
Cenp-C | cid | FBpp0088911 | FBpp0086787 | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | Histone H3-like centromeric protein cid; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. | 0.973 |
His2A:CG31618 | Cenp-C | FBpp0085249 | FBpp0088911 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | 0.664 |
His2A:CG31618 | His4:CG31611 | FBpp0085249 | FBpp0085280 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | 0.954 |
His2A:CG31618 | His4:CG33883 | FBpp0085249 | FBpp0091128 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Protein heterodimerization activity; DNA binding; histone binding. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation. | 0.954 |
His2A:CG31618 | His4:CG33885 | FBpp0085249 | FBpp0091130 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation. | 0.954 |
His2A:CG31618 | His4:CG33887 | FBpp0085249 | FBpp0091132 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | 0.954 |
His2A:CG31618 | His4:CG33889 | FBpp0085249 | FBpp0091134 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Protein heterodimerization activity; DNA binding; histone binding. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation. | 0.954 |
His2A:CG31618 | His4:CG33901 | FBpp0085249 | FBpp0091146 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | His4:CG33901 (His4:CG33901) encodes a histone H4 replacement variant that is part of the nucleosome core. It is the predominant histone H4 in non-dividing cells. Its amino acid sequence is identical to the cell-cycle regulated histone encoded by His4. | 0.954 |
His2A:CG31618 | His4r | FBpp0085249 | FBpp0082423 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.999 |
His2A:CG31618 | cal1 | FBpp0085249 | FBpp0082841 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Chromosome alignment defect 1 (cal1) encodes a protein that is required for maintenance of the epigenetic marks specifying centromeres. It binds to newly synthesized centromere-specific histone H3 variant encoded by cid and recruits it to the centromere by binding to the centromere protein encoded by Cenp-C. | 0.491 |
His2A:CG31618 | cid | FBpp0085249 | FBpp0086787 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H3-like centromeric protein cid; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. | 0.948 |
His4:CG31611 | His2A:CG31618 | FBpp0085280 | FBpp0085249 | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.954 |
His4:CG31611 | His4:CG33883 | FBpp0085280 | FBpp0091128 | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | Protein heterodimerization activity; DNA binding; histone binding. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation. | 0.983 |
His4:CG31611 | His4:CG33885 | FBpp0085280 | FBpp0091130 | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation. | 0.983 |
His4:CG31611 | His4:CG33887 | FBpp0085280 | FBpp0091132 | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | 0.983 |
His4:CG31611 | His4:CG33889 | FBpp0085280 | FBpp0091134 | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | Protein heterodimerization activity; DNA binding; histone binding. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation. | 0.983 |
His4:CG31611 | His4:CG33901 | FBpp0085280 | FBpp0091146 | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | His4:CG33901 (His4:CG33901) encodes a histone H4 replacement variant that is part of the nucleosome core. It is the predominant histone H4 in non-dividing cells. Its amino acid sequence is identical to the cell-cycle regulated histone encoded by His4. | 0.983 |
His4:CG31611 | His4r | FBpp0085280 | FBpp0082423 | Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.979 |