STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ClC-bChloride channel-b (ClC-b) encodes a chloride transmembrane transporter involved in phagocytosis. (813 aa)    
Predicted Functional Partners:
CG14969
GH26007p.
   
 0.995
CG4847
RH39096p; Cysteine-type peptidase activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: proteolysis involved in cellular protein catabolic process; proteolysis; multicellular organism reproduction; Belongs to the peptidase C1 family.
      
 0.651
Prp3
Precursor RNA processing 3 (Prp3) encodes a protein that regulates chromatin silencing.
   
  
 0.643
Ocrl
Oculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis.
   
  
 0.623
MED19
Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
      
 0.620
Clc
Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
      
 0.618
trus
Toys are us.
      
 0.602
Nhe1
Sodium/hydrogen exchanger; Sodium:proton antiporter activity; potassium:proton antiporter activity. It is involved in the biological process described with: sodium ion transport; regulation of intracellular pH; potassium ion transmembrane transport; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
  
  
 0.570
Trpml
Transient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation.
    
 
 0.556
icln
Methylosome subunit pICln; Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm comple [...]
   
  
 0.552
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.