node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cep135 | Plp | FBpp0292437 | FBpp0297121 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | 0.885 |
Cep135 | Rcd4 | FBpp0292437 | FBpp0079268 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | Reduction in Cnn dots 4 (Rcd4) encodes a protein involved in the regulation of the number of centrosomes per cell. | 0.626 |
Cep135 | Sas-4 | FBpp0292437 | FBpp0081088 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | Spindle assembly abnormal 4 (Sas-4) encodes a centriole protein that is essential for centriole assembly. It is recruited to centrioles through an interaction with the centriole protein encoded by ana2, and it helps recruit microtubules to the centriole. | 0.993 |
Cep135 | Sas-6 | FBpp0292437 | FBpp0084912 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function. Required for sperm cilium basal body elongation together with Cep135 and Ana2. | 0.995 |
Cep135 | ana1 | FBpp0292437 | FBpp0306443 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | Anastral spindle 1 (ana1) encodes a cytoplasmic protein located in the centrioles, including the sperm giant centriole and proximal centriole-like structure, which assists in centrioles formation. Its roles include coordinated movement behavior, sperm motility, and fertility. | 0.977 |
Cep135 | ana2 | FBpp0292437 | FBpp0087766 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | Anastral spindle 2 (ana2) encodes a centriole protein that is essential for centriole assembly, promoting the assembly of the central "cartwheel" structure. It may also have an independent role in promoting asymmetric divisions in larval neuroblasts. | 0.982 |
Cep135 | ana3 | FBpp0292437 | FBpp0087015 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | Anastral spindle 3 (ana3) encodes a centriole and basal body localized protein that is required for the proper function of these organelles. | 0.842 |
Cep135 | asl | FBpp0292437 | FBpp0078392 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | Asterless (asl) encodes a component of the centriole that is required for centrosome function. It contributes to asymmetric cell division, sperm development and centriole replication and elongation. | 0.952 |
Cep135 | spd-2 | FBpp0292437 | FBpp0075122 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | Spindle defective 2 (spd-2) encodes a centriole and centrosome protein that is primarily involved in centrosome assembly. Together with the product of cnn, it helps to assemble a "scaffold" around the mother centriole that can recruit other centrosomal proteins to the centrosome during mitosis. | 0.918 |
Fancd2 | ana3 | FBpp0083399 | FBpp0087015 | Fanconi anemia complementation group D2 protein; DNA polymerase binding. It is involved in the biological process described with: synapsis; interstrand cross-link repair; intra-S DNA damage checkpoint; double-strand break repair involved in meiotic recombination; DNA repair. | Anastral spindle 3 (ana3) encodes a centriole and basal body localized protein that is required for the proper function of these organelles. | 0.686 |
Plp | Cep135 | FBpp0297121 | FBpp0292437 | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | 0.885 |
Plp | Rcd4 | FBpp0297121 | FBpp0079268 | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | Reduction in Cnn dots 4 (Rcd4) encodes a protein involved in the regulation of the number of centrosomes per cell. | 0.489 |
Plp | Sas-4 | FBpp0297121 | FBpp0081088 | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | Spindle assembly abnormal 4 (Sas-4) encodes a centriole protein that is essential for centriole assembly. It is recruited to centrioles through an interaction with the centriole protein encoded by ana2, and it helps recruit microtubules to the centriole. | 0.980 |
Plp | Sas-6 | FBpp0297121 | FBpp0084912 | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function. Required for sperm cilium basal body elongation together with Cep135 and Ana2. | 0.912 |
Plp | ana1 | FBpp0297121 | FBpp0306443 | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | Anastral spindle 1 (ana1) encodes a cytoplasmic protein located in the centrioles, including the sperm giant centriole and proximal centriole-like structure, which assists in centrioles formation. Its roles include coordinated movement behavior, sperm motility, and fertility. | 0.877 |
Plp | ana2 | FBpp0297121 | FBpp0087766 | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | Anastral spindle 2 (ana2) encodes a centriole protein that is essential for centriole assembly, promoting the assembly of the central "cartwheel" structure. It may also have an independent role in promoting asymmetric divisions in larval neuroblasts. | 0.866 |
Plp | ana3 | FBpp0297121 | FBpp0087015 | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | Anastral spindle 3 (ana3) encodes a centriole and basal body localized protein that is required for the proper function of these organelles. | 0.673 |
Plp | asl | FBpp0297121 | FBpp0078392 | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | Asterless (asl) encodes a component of the centriole that is required for centrosome function. It contributes to asymmetric cell division, sperm development and centriole replication and elongation. | 0.976 |
Plp | spd-2 | FBpp0297121 | FBpp0075122 | Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. | Spindle defective 2 (spd-2) encodes a centriole and centrosome protein that is primarily involved in centrosome assembly. Together with the product of cnn, it helps to assemble a "scaffold" around the mother centriole that can recruit other centrosomal proteins to the centrosome during mitosis. | 0.966 |
Rcd4 | Cep135 | FBpp0079268 | FBpp0292437 | Reduction in Cnn dots 4 (Rcd4) encodes a protein involved in the regulation of the number of centrosomes per cell. | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. | 0.626 |