STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Prp8pre-mRNA processing factor 8 (Prp8) is an essential gene that encodes the largest and most highly conserved splicing factor. It is a core component of the U5 snRNP, with a key function in pre-mRNA processing catalyzed by the spliceosome. (2396 aa)    
Predicted Functional Partners:
l(3)72Ab
Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily.
   
 0.999
CG4849
LD28793p; U5 snRNA binding; GTP binding; GTPase activity; translation elongation factor activity. It is involved in the biological process described with: mRNA splicing, via spliceosome; translational elongation; positive regulation of gene expression.
   
 0.999
CG6841
LD04472p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; spliceosomal tri-snRNP complex assembly; regulation of alternative mRNA splicing, via spliceosome.
   
 0.999
CG12320
Uncharacterized protein, isoform A; It is involved in the biological process described with: spliceosomal tri-snRNP complex assembly.
   
 0.999
CG10333
RH55640p; ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of defense response to virus.
   
 0.998
CG3436
GM13767p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mitotic cell cycle.
   
 0.998
Prp31
Pre-mRNA processing factor 31 (Prp31) encodes a splicing factor associated with U4/U6.U5 tri-snRNP. It plays important roles in pre-mRNA splicing and other steps of RNA processing. Prp31 is essential for photoreceptor development.
   
 
 0.997
Prp3
Precursor RNA processing 3 (Prp3) encodes a protein that regulates chromatin silencing.
   
 
 0.996
SmF
Small ribonucleoprotein particle protein SmF (SmF) encodes an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. It also forms a heterotrimeric sub-complex with the products of SmE and SNRPG.
   
 0.996
SNRPG
Probable small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly. Plays role in pre-mRNA splicing as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity).
   
 0.995
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.