node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cul2 | Cul3 | FBpp0085254 | FBpp0291369 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | 0.903 |
Cul2 | Cul4 | FBpp0085254 | FBpp0290569 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome; Belongs to the cullin family. | 0.660 |
Cul2 | Cul5 | FBpp0085254 | FBpp0084786 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | FI20194p1; Cullin 5 (Cul5) is expressed in both neuronal and non-neuronal cells (such as in fusion sites of embryonic trachea). Reduction of the product of Cul5 in neuronal cells results in an increase in number of synaptic boutons in the larval neuromuscular junction; Belongs to the cullin family. | 0.915 |
Cul2 | EloB | FBpp0085254 | FBpp0083354 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. | 0.999 |
Cul2 | EloC | FBpp0085254 | FBpp0085725 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Elongin C (EloC) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. | 0.999 |
Cul2 | Nedd8 | FBpp0085254 | FBpp0309711 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | 0.995 |
Cul2 | Roc2 | FBpp0085254 | FBpp0291421 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Regulator of cullins 2 (Roc2) encodes a C2H2 type zinc finger protein that binds specifically to the product of Cul5 and recruits ubiquitin-charged E2 to the CRL5 E3 ubiquitin ligase complex, which functions during oogenesis. | 0.954 |
Cul2 | UbcE2M | FBpp0085254 | FBpp0304449 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Nedd8-conjugating enzyme UbcE2M; Accepts the ubiquitin-like protein Nedd8 from the Uba3-APP- BP1 E1 complex and catalyzes its covalent attachment to other proteins. Required for Cul1 and Cul3 neddylation. Negatively regulates full- length ci stability and hedgehog signaling. | 0.764 |
Cul2 | gus | FBpp0085254 | FBpp0301582 | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | Gustavus (gus) encodes a cullin-RING ubiquitin E3 ligase specificity receptor. It interacts genetically and physically with the product of Cul5, and putatively regulates stability of target proteins including the one encoded by vas. It is involved in oogenesis and germ cell maintenance. | 0.495 |
Cul3 | Cul2 | FBpp0291369 | FBpp0085254 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | 0.903 |
Cul3 | Cul4 | FBpp0291369 | FBpp0290569 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome; Belongs to the cullin family. | 0.603 |
Cul3 | Cul5 | FBpp0291369 | FBpp0084786 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | FI20194p1; Cullin 5 (Cul5) is expressed in both neuronal and non-neuronal cells (such as in fusion sites of embryonic trachea). Reduction of the product of Cul5 in neuronal cells results in an increase in number of synaptic boutons in the larval neuromuscular junction; Belongs to the cullin family. | 0.922 |
Cul3 | EloB | FBpp0291369 | FBpp0083354 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. | 0.789 |
Cul3 | EloC | FBpp0291369 | FBpp0085725 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | Elongin C (EloC) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. | 0.901 |
Cul3 | Nedd8 | FBpp0291369 | FBpp0309711 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | 0.995 |
Cul3 | Roc2 | FBpp0291369 | FBpp0291421 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | Regulator of cullins 2 (Roc2) encodes a C2H2 type zinc finger protein that binds specifically to the product of Cul5 and recruits ubiquitin-charged E2 to the CRL5 E3 ubiquitin ligase complex, which functions during oogenesis. | 0.907 |
Cul3 | UbcE2M | FBpp0291369 | FBpp0304449 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | Nedd8-conjugating enzyme UbcE2M; Accepts the ubiquitin-like protein Nedd8 from the Uba3-APP- BP1 E1 complex and catalyzes its covalent attachment to other proteins. Required for Cul1 and Cul3 neddylation. Negatively regulates full- length ci stability and hedgehog signaling. | 0.939 |
Cul3 | gus | FBpp0291369 | FBpp0301582 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | Gustavus (gus) encodes a cullin-RING ubiquitin E3 ligase specificity receptor. It interacts genetically and physically with the product of Cul5, and putatively regulates stability of target proteins including the one encoded by vas. It is involved in oogenesis and germ cell maintenance. | 0.488 |
Cul4 | Cul2 | FBpp0290569 | FBpp0085254 | Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome; Belongs to the cullin family. | Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. | 0.660 |
Cul4 | Cul3 | FBpp0290569 | FBpp0291369 | Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome; Belongs to the cullin family. | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. | 0.603 |