STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TapdeltaTranslocon-associated protein delta, isoform A; Signal sequence binding. It is involved in the biological process described with: protein retention in ER lumen (166 aa)    
Predicted Functional Partners:
SsRbeta
Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins
   
 0.999
CG5885
CG5885, isoform A; It is involved in the biological process described with: cotranslational protein targeting to membrane
   
 0.999
Sec61beta
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum
   
  
 0.999
Sec61gamma
Protein transport protein Sec61 gamma-2 subunit; Necessary for protein translocation in the endoplasmic reticulum
   
    0.979
l(1)G0320
Lethal (1) G0320, isoform A; Signal sequence binding
   
 0.976
Ostgamma
Oligosaccharide transferase gamma subunit; It is involved in the biological process described with: encapsulation of foreign target
   
   0.968
twr
Signal peptidase complex catalytic subunit SEC11; Peptidase activity; serine-type peptidase activity. It is involved in the biological process described with: signal peptide processing
   
  
 0.951
bai
Transmembrane emp24 domain-containing protein bai; Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected; Belongs to the EMP24/GP25L family
   
  
 0.951
Sec61alpha
Sec61 alpha subunit is a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. Sec61 alpha is a subunit of the Sec61 heterotrimer that forms the core of translocon channel
   
 
 0.920
Crc
Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity)
   
  
 0.916
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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