STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nclbPeriodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the localization to the nucleolus of Cdk7, a regulator of the Pol I- elongation factor TFIIH. Acts as regulator of cell proliferation and tissue growth as part of the TORC1 and Myc signaling pathway in response to nutrients. Required in males for both germline stem cell (GSC) maintenance and early stages of germ cell differentiation of germ cell cysts. Not required for female germline stem cell [...] (459 aa)    
Predicted Functional Partners:
CG11583
Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.
   
 
 0.978
CG1542
Probable rRNA-processing protein EBP2 homolog; Required for the processing of the 27S pre-rRNA. Belongs to the EBP2 family.
   
 
 0.964
CG12288
Uncharacterized protein; mRNA binding; nucleic acid binding.
   
 
 0.962
l(2)09851
Lethal (2) 09851, isoform A.
   
  
 0.962
CG1671
LD47550p; U3 snoRNA binding. It is involved in the biological process described with: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
   
  
 0.950
Non3
Ribosome production factor 2 homolog; Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs; Belongs to the RPF2 family.
   
 
 0.948
CG13096
Ribosomal L1 domain-containing protein CG13096; RNA binding. It is involved in the biological process described with: maturation of LSU-rRNA; Belongs to the universal ribosomal protein uL1 family. Highly divergent.
   
 
 0.941
CG6937
RRM domain-containing protein; mRNA binding; RNA binding. It is involved in the biological process described with: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
   
  
 0.936
Ns2
Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
   
 
 0.928
CG8064
GH01043p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA.
   
  
 0.925
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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