STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
oysOysgedart, isoform A; Oysgedart (oys) encodes a lysophospholipid acyltransferase that is required redundantly with the product of nes for germ cell migration and spermatid individualization; Belongs to the membrane-bound acyltransferase family. (722 aa)    
Predicted Functional Partners:
CG15912
Uncharacterized protein; Hydrolase activity.
      
 0.896
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with: phosphatidic acid biosynthetic process; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
   
 
 0.737
Agpat2
1-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with: behavioral response to ethanol; phosphatidic acid biosynthetic process.
   
 
 0.737
LPCAT
Lysophosphatidylcholine acyltransferase; Acetyltransferase which mediates the conversion of 1-acyl-sn- glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). Has a calcium-independent activity (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1- myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in the regulation of lipid droplet number and size.
   
 
 0.667
GIIIspla2
Phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process.
      
 0.661
CG33331
Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
      
 0.658
Cds
Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...]
      
 0.649
CG8112
O-acyltransferase activity; cholesterol O-acyltransferase activity. It is involved in the biological process described with: cholesterol homeostasis; cholesterol metabolic process; cholesterol esterification.
      
 0.636
Pisd
Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
    
 
 0.621
Taz
Tafazzin (Taz) encodes a mitochondrial phospholipid-lysophospholipid transacylase that exchange acyl groups between cardiolipin molecules and other phospholipids. It plays a critical role in maintaining a normal cardiolipin composition required for optimal mitochondrial function.
      
 0.619
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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