STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
wun2Wunen-2, isoform A; Wunen-2 (wun2) encodes a lipid phosphate phosphatase, an enzyme with an active site predicted to face extracellularly. It is required for germ cell migration and survival, acting partially redundantly with its paralog wun. (350 aa)    
Predicted Functional Partners:
bwa
Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family.
     
 0.937
Sk2
Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation.
   
 0.928
mdy
O-acyltransferase; Midway (mdy) encodes an acyl coenzyme A: diacylglycerol acyltransferase that functions in the formation of triglycerides. Lack of mdy leads to female sterility and impaired fat metabolism in larvae and adults.
    
 0.927
Sply
Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily.
    
 0.916
CDase
Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family.
     
 0.913
schlank
Schlank, isoform A; Schlank (schlank) encodes a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators.
    
 0.912
Sk1
Sphingosine kinase 1 (Sk1) encodes an enzyme that catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate, a bioactive lipid mediator. It regulates cell proliferation, differentiation, endolysosomal trafficking and muscle cell repair.
   
 0.912
CG10425
LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process.
    
 0.911
Cds
Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...]
     
 0.908
CG33116
FI05338p; Phosphotransferase activity, for other substituted phosphate groups; ethanolaminephosphotransferase activity. It is involved in the biological process described with: phosphatidylethanolamine biosynthetic process; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
   
 0.907
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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