node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aos1 | PCNA | FBpp0082065 | FBpp0085619 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | 0.576 |
Aos1 | Rad60 | FBpp0082065 | FBpp0083780 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | 0.906 |
Aos1 | Su(var)2-10 | FBpp0082065 | FBpp0087651 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination. | 0.946 |
Aos1 | Uba2 | FBpp0082065 | FBpp0076457 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | SUMO-activating enzyme subunit; Ubiquitin-like activating enzyme 2 (Uba2) encodes one of two subunits (along with the product of Aos1) of the heterodimeric SUMO activating enzyme. It contains the catalytic cysteine residue that first becomes adenylated using ATP and that then forms a thioester linkage to the C-terminal end of SUMO; Belongs to the ubiquitin-activating E1 family. | 0.999 |
Aos1 | lwr | FBpp0082065 | FBpp0301731 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo. | 0.998 |
Aos1 | smt3 | FBpp0082065 | FBpp0078984 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily. | 0.998 |
CG30122 | Su(var)2-10 | FBpp0290145 | FBpp0087651 | Uncharacterized protein, isoform C; It is involved in the biological process described with: mRNA splicing, via spliceosome. | Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination. | 0.896 |
PCNA | Aos1 | FBpp0085619 | FBpp0082065 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | 0.576 |
PCNA | Rad60 | FBpp0085619 | FBpp0083780 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | 0.820 |
PCNA | Su(var)2-10 | FBpp0085619 | FBpp0087651 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination. | 0.854 |
PCNA | lwr | FBpp0085619 | FBpp0301731 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo. | 0.891 |
PCNA | smt3 | FBpp0085619 | FBpp0078984 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily. | 0.928 |
Rad60 | Aos1 | FBpp0083780 | FBpp0082065 | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | 0.906 |
Rad60 | PCNA | FBpp0083780 | FBpp0085619 | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | 0.820 |
Rad60 | Su(var)2-10 | FBpp0083780 | FBpp0087651 | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination. | 0.904 |
Rad60 | Top1 | FBpp0083780 | FBpp0099689 | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex (By similarity). Introduces a single-strand break via transesterification at a target site in duplex DNA (By similarity). The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand (By similarity). The free DNA strand then undergoes passage around the unb [...] | 0.622 |
Rad60 | Uba2 | FBpp0083780 | FBpp0076457 | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | SUMO-activating enzyme subunit; Ubiquitin-like activating enzyme 2 (Uba2) encodes one of two subunits (along with the product of Aos1) of the heterodimeric SUMO activating enzyme. It contains the catalytic cysteine residue that first becomes adenylated using ATP and that then forms a thioester linkage to the C-terminal end of SUMO; Belongs to the ubiquitin-activating E1 family. | 0.913 |
Rad60 | lwr | FBpp0083780 | FBpp0301731 | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo. | 0.936 |
Rad60 | qjt | FBpp0083780 | FBpp0074985 | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | Quijote, isoform A; Quijote (qjt) encodes a SUMO E3 ligase and a highly conserved subunit of the Smc5/6 complex. It is enriched in heterochromatin and recruited to heterochromatic double-strand break repair sites. | 0.896 |
Rad60 | smt3 | FBpp0083780 | FBpp0078984 | Uncharacterized protein CG4449; It is involved in the biological process described with: double-strand break repair via homologous recombination. | Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily. | 0.612 |