node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ance-4 | Hn | FBpp0087745 | FBpp0076523 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Henna (Hn) encodes a tryptophan phenylalanine hydroxylase. It is a dual function enzyme: it hydroxylates both phenylalanine to generate tyrosine, as well as tryptophan to generate the precursor for peripheral (non-neuronal) serotonin. It is also involved in pteridine synthesis. | 0.741 |
Ance-4 | Ide | FBpp0087745 | FBpp0271781 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | 0.670 |
Ance-4 | Nep1 | FBpp0087745 | FBpp0310420 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. | 0.840 |
Ance-4 | Nep2 | FBpp0087745 | FBpp0293663 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-2, soluble form; Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues. Functions in female fertility, embryogenesis and memory formation. Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates. Also required for normal patterns of hatching due to its important role in early embryonic development. Required in the dorsal paired medial neurons for the proper formation of middle-term memory. Also required in the mus [...] | 0.841 |
Ance-4 | Nep3 | FBpp0087745 | FBpp0300207 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-3; Metalloendoprotease which is required in the dorsal paired medial neurons for the proper formation of long-term (LTM) and middle- term memories (MTM). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep2 and Nep4 in normal LTM formation; Belongs to the peptidase M13 family. | 0.840 |
Ance-4 | Nep4 | FBpp0087745 | FBpp0083345 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-4; Metalloendoprotease which cleaves peptides at the amino side of hydrophobic residues - such as the hormones Akh and Dh31, and the neuropeptides Allatostatins (AST1, AST2, AST3 and AST4), Crz, Drosulfakinins (DSK-I and DSK-II), Lk, sNPF and the tachykinin peptides TK-1, TK-2, TK-4 and TK-5. Functions in female fertility, memory formation and may also act in regulating insulin signaling and food intake. Likely to be involved in controlling feeding behavior and the expression of insulin-like peptides by cleaving various regulatory peptides that include certain Drosulfakinins [...] | 0.840 |
Ance-4 | Nep6 | FBpp0087745 | FBpp0073523 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin 6, isoform A; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.865 |
Ance-4 | Nepl12 | FBpp0087745 | FBpp0081559 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-like 12; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.843 |
Ance-4 | Nepl20 | FBpp0087745 | FBpp0084699 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-like 20; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.841 |
Ance-4 | Tace | FBpp0087745 | FBpp0084917 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. | 0.582 |
Hn | Ance-4 | FBpp0076523 | FBpp0087745 | Henna (Hn) encodes a tryptophan phenylalanine hydroxylase. It is a dual function enzyme: it hydroxylates both phenylalanine to generate tyrosine, as well as tryptophan to generate the precursor for peripheral (non-neuronal) serotonin. It is also involved in pteridine synthesis. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.741 |
Ide | Ance-4 | FBpp0271781 | FBpp0087745 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.670 |
Ide | Nep1 | FBpp0271781 | FBpp0310420 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. | 0.921 |
Ide | Nep2 | FBpp0271781 | FBpp0293663 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Neprilysin-2, soluble form; Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues. Functions in female fertility, embryogenesis and memory formation. Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates. Also required for normal patterns of hatching due to its important role in early embryonic development. Required in the dorsal paired medial neurons for the proper formation of middle-term memory. Also required in the mus [...] | 0.921 |
Ide | Nep3 | FBpp0271781 | FBpp0300207 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Neprilysin-3; Metalloendoprotease which is required in the dorsal paired medial neurons for the proper formation of long-term (LTM) and middle- term memories (MTM). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep2 and Nep4 in normal LTM formation; Belongs to the peptidase M13 family. | 0.921 |
Ide | Nep4 | FBpp0271781 | FBpp0083345 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Neprilysin-4; Metalloendoprotease which cleaves peptides at the amino side of hydrophobic residues - such as the hormones Akh and Dh31, and the neuropeptides Allatostatins (AST1, AST2, AST3 and AST4), Crz, Drosulfakinins (DSK-I and DSK-II), Lk, sNPF and the tachykinin peptides TK-1, TK-2, TK-4 and TK-5. Functions in female fertility, memory formation and may also act in regulating insulin signaling and food intake. Likely to be involved in controlling feeding behavior and the expression of insulin-like peptides by cleaving various regulatory peptides that include certain Drosulfakinins [...] | 0.921 |
Ide | Nep6 | FBpp0271781 | FBpp0073523 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Neprilysin 6, isoform A; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.927 |
Ide | Nepl12 | FBpp0271781 | FBpp0081559 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Neprilysin-like 12; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.922 |
Ide | Nepl20 | FBpp0271781 | FBpp0084699 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Neprilysin-like 20; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.921 |
Nep1 | Ance-4 | FBpp0310420 | FBpp0087745 | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.840 |