STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmem63RE44586p; Calcium activated cation channel activity. (760 aa)    
Predicted Functional Partners:
CG6230
Cation-transporting ATPase; Ion transmembrane transporter activity, phosphorylative mechanism; nucleotide binding; ATPase activity. It is involved in the biological process described with: cellular calcium ion homeostasis; cation transport; transmembrane transport; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
      
 0.842
CG17272
GEO07376p1; Calcium ion binding; enzyme regulator activity. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization.
      
 0.838
CG17271
Uncharacterized protein, isoform A; Calcium ion binding. It is involved in the biological process described with: multicellular organism reproduction.
      
 0.791
CG1951
LD39455p; ATP binding. It is involved in the biological process described with: protein phosphorylation; multicellular organism reproduction.
   
  
 0.692
Piezo
Piezo-type mechanosensitive ion channel component; Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Plays a major role in nociception (response to strong or painful touch) ; Belongs to the PIEZO (TC 1.A.75) family.
      
 0.682
Arfrp1
ADP-ribosylation factor related protein 1; GTP binding. It is involved in the biological process described with: protein localization to organelle; Golgi to plasma membrane protein transport; intracellular protein transport.
 
      0.630
CG5823
HL05730p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent ERAD pathway; protein polyubiquitination.
      
 0.628
AnxB11
Annexin B11; Calcium ion binding; calcium-dependent phospholipid binding; Belongs to the annexin family.
   
  
 0.619
Edem2
alpha-1,2-Mannosidase; ER degradation enhancer, mannosidase alpha-like 2 (Edem2) encodes a lectin involved in the degradation of proteins during endoplasmic reticulum (ER) stress, which is generated by the presence of unfolded proteins in the ER; Belongs to the glycosyl hydrolase 47 family.
   
  
 0.609
muskelin
Muskelin, isoform A; It is involved in the biological process described with: regulation of cell-matrix adhesion; oocyte maturation.
   
  
 0.602
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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