node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG6873 | pnut | FBpp0074378 | FBpp0087869 | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | Peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. | 0.583 |
CG6873 | scra | FBpp0074378 | FBpp0087986 | IP04855p; Actin filament binding. It is involved in the biological process described with: actin filament depolymerization; cell motility; actin filament severing; Belongs to the actin-binding proteins ADF family. | Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...] | 0.731 |
Hil | pnut | FBpp0085567 | FBpp0087869 | Hillarin (Hil) encodes a W180-domain protein that affects cytokinesis through interactions with the Septin family member encoded by pnut in the developing nervous system; Belongs to the transglutaminase-like superfamily. | Peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. | 0.600 |
Orc6 | pnut | FBpp0087566 | FBpp0087869 | Origin recognition complex subunit 6; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). | Peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. | 0.944 |
Sep1 | Sep2 | FBpp0076897 | FBpp0083352 | Septin-1; Involved in cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Septin-2; Involved in cytokinesis. | 0.999 |
Sep1 | Sep4 | FBpp0076897 | FBpp0074142 | Septin-1; Involved in cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Septin 4, isoform A; Molecular adaptor activity; GTP binding; GTPase activity. It is involved in the biological process described with: cellular protein localization; cytoskeleton-dependent cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.573 |
Sep1 | Sep5 | FBpp0076897 | FBpp0087952 | Septin-1; Involved in cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Septin 5 (Sep5) encodes a member of the septin family of GTP-binding proteins. Septins form hetero-oligomeric filaments and rings that have roles in cytokinesis, cell polarity and membrane rigidity. Sep5 is not essential for development, but mutants display a synthetic lethal pupal phenotype when combined with mutations in its paralog Sep2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.959 |
Sep1 | pnut | FBpp0076897 | FBpp0087869 | Septin-1; Involved in cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. | 0.989 |
Sep1 | scra | FBpp0076897 | FBpp0087986 | Septin-1; Involved in cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...] | 0.642 |
Sep2 | Sep1 | FBpp0083352 | FBpp0076897 | Septin-2; Involved in cytokinesis. | Septin-1; Involved in cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.999 |
Sep2 | Sep4 | FBpp0083352 | FBpp0074142 | Septin-2; Involved in cytokinesis. | Septin 4, isoform A; Molecular adaptor activity; GTP binding; GTPase activity. It is involved in the biological process described with: cellular protein localization; cytoskeleton-dependent cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.902 |
Sep2 | Sep5 | FBpp0083352 | FBpp0087952 | Septin-2; Involved in cytokinesis. | Septin 5 (Sep5) encodes a member of the septin family of GTP-binding proteins. Septins form hetero-oligomeric filaments and rings that have roles in cytokinesis, cell polarity and membrane rigidity. Sep5 is not essential for development, but mutants display a synthetic lethal pupal phenotype when combined with mutations in its paralog Sep2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.853 |
Sep2 | pnut | FBpp0083352 | FBpp0087869 | Septin-2; Involved in cytokinesis. | Peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. | 0.998 |
Sep2 | scra | FBpp0083352 | FBpp0087986 | Septin-2; Involved in cytokinesis. | Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...] | 0.850 |
Sep4 | Sep1 | FBpp0074142 | FBpp0076897 | Septin 4, isoform A; Molecular adaptor activity; GTP binding; GTPase activity. It is involved in the biological process described with: cellular protein localization; cytoskeleton-dependent cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Septin-1; Involved in cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.573 |
Sep4 | Sep2 | FBpp0074142 | FBpp0083352 | Septin 4, isoform A; Molecular adaptor activity; GTP binding; GTPase activity. It is involved in the biological process described with: cellular protein localization; cytoskeleton-dependent cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Septin-2; Involved in cytokinesis. | 0.902 |
Sep4 | Sep5 | FBpp0074142 | FBpp0087952 | Septin 4, isoform A; Molecular adaptor activity; GTP binding; GTPase activity. It is involved in the biological process described with: cellular protein localization; cytoskeleton-dependent cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Septin 5 (Sep5) encodes a member of the septin family of GTP-binding proteins. Septins form hetero-oligomeric filaments and rings that have roles in cytokinesis, cell polarity and membrane rigidity. Sep5 is not essential for development, but mutants display a synthetic lethal pupal phenotype when combined with mutations in its paralog Sep2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.893 |
Sep4 | pnut | FBpp0074142 | FBpp0087869 | Septin 4, isoform A; Molecular adaptor activity; GTP binding; GTPase activity. It is involved in the biological process described with: cellular protein localization; cytoskeleton-dependent cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. | 0.706 |
Sep4 | scra | FBpp0074142 | FBpp0087986 | Septin 4, isoform A; Molecular adaptor activity; GTP binding; GTPase activity. It is involved in the biological process described with: cellular protein localization; cytoskeleton-dependent cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...] | 0.592 |
Sep5 | Sep1 | FBpp0087952 | FBpp0076897 | Septin 5 (Sep5) encodes a member of the septin family of GTP-binding proteins. Septins form hetero-oligomeric filaments and rings that have roles in cytokinesis, cell polarity and membrane rigidity. Sep5 is not essential for development, but mutants display a synthetic lethal pupal phenotype when combined with mutations in its paralog Sep2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Septin-1; Involved in cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.959 |