STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nitoSpenito, isoform A; mRNA binding; nucleotide binding; nucleic acid binding. It is involved in the biological process described with: wing disc pattern formation; mRNA splicing, via spliceosome; compound eye development; positive regulation of Wnt signaling pathway; neurogenesis (793 aa)    
Predicted Functional Partners:
CG7818
Methyltransferase-like protein 14 homolog; Probable methyltransferase
   
 0.991
fl(2)d
Pre-mRNA-splicing regulator female-lethal(2)D; Required for male and female viability, sex determination and dosage compensation. Involved in the female- specific splicing of Sxl transcripts. Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b; Belongs to the fl(2)d family
   
 0.989
vir
Protein virilizer; Required for male and female viability, sex determination and dosage compensation. Involved in the female- specific splicing of Sxl transcripts. Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b; Belongs to the vir family
   
 
 0.986
Ime4
Probable N6-adenosine-methyltransferase MT-A70-like protein; Probable N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites in mRNA isolated, may play a role in the efficiency of mRNA splicing, transport or translation (By similarity)
   
 0.972
YT521-B
YT521-B, isoform A; RNA binding. It is involved in the biological process described with: RNA metabolic process
   
  
 0.875
CG3862
annotation not available
   
  
 0.851
CG6422
annotation not available
   
  
 0.789
larp
La-related protein 1; RNA-binding protein required during male meiosis and development of the syncytial embryo. Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation
    
 
 0.769
CG8671
CG8671, isoform A; It is involved in the biological process described with: dsRNA transport
      
 0.750
Sxl
Protein sex-lethal; Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex-determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X- linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific [...]
    
 
 0.748
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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