node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG30496 | Coq4 | FBpp0088000 | FBpp0289097 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. | 0.802 |
CG30496 | Coq6 | FBpp0088000 | FBpp0078759 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.820 |
CG30496 | Coq7 | FBpp0088000 | FBpp0070924 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. | 0.948 |
CG30496 | Coq8 | FBpp0088000 | FBpp0073530 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | Coenzyme Q8; Protein kinase activity; kinase activity. It is involved in the biological process described with: mitochondrial electron transport, ubiquinol to cytochrome c; ubiquinone biosynthetic process. | 0.852 |
CG30496 | Coq9 | FBpp0088000 | FBpp0087999 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | 0.905 |
CG30496 | Cul1 | FBpp0088000 | FBpp0087922 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...] | 0.844 |
CG30496 | Cul6 | FBpp0088000 | FBpp0075633 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | Cullin 6; Ubiquitin-protein transferase activity; ubiquitin protein ligase binding; Belongs to the cullin family. | 0.844 |
CG30496 | Fkbp59 | FBpp0088000 | FBpp0309663 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | FK506-binding protein 59kD (Fkbp59) encodes a peptidylprolyl isomerase involved in the regulation of calcium transport and phototransduction. | 0.802 |
CG30496 | Roc1a | FBpp0088000 | FBpp0300874 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | RING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] | 0.891 |
CG30496 | Roc1b | FBpp0088000 | FBpp0072446 | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | RING-box protein 1B; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Belongs to the RING-box family. | 0.891 |
Coq4 | CG30496 | FBpp0289097 | FBpp0088000 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | 0.802 |
Coq4 | Coq6 | FBpp0289097 | FBpp0078759 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.990 |
Coq4 | Coq7 | FBpp0289097 | FBpp0070924 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. | 0.983 |
Coq4 | Coq8 | FBpp0289097 | FBpp0073530 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. | Coenzyme Q8; Protein kinase activity; kinase activity. It is involved in the biological process described with: mitochondrial electron transport, ubiquinol to cytochrome c; ubiquinone biosynthetic process. | 0.969 |
Coq4 | Coq9 | FBpp0289097 | FBpp0087999 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | 0.668 |
Coq6 | CG30496 | FBpp0078759 | FBpp0088000 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | RE73310p; Ubiquitin-protein transferase inhibitor activity; ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of protein ubiquitination. | 0.820 |
Coq6 | Coq4 | FBpp0078759 | FBpp0289097 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. | 0.990 |
Coq6 | Coq7 | FBpp0078759 | FBpp0070924 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. | 0.987 |
Coq6 | Coq8 | FBpp0078759 | FBpp0073530 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Coenzyme Q8; Protein kinase activity; kinase activity. It is involved in the biological process described with: mitochondrial electron transport, ubiquinol to cytochrome c; ubiquinone biosynthetic process. | 0.976 |
Coq6 | Coq9 | FBpp0078759 | FBpp0087999 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | 0.698 |