STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tsp42EfTetraspanin; It is involved in the biological process described with: determination of adult lifespan. (220 aa)    
Predicted Functional Partners:
CG17574
Uncharacterized protein, isoform I.
      
 0.790
Tsp3A
Tetraspanin 3A (Tsp3A) encodes a member of the tetraspanin superfamily. With two other tetraspanins, encoded by Tsp26A and Tsp86D, it regulates the trafficking of the product of kuz and consequently Notch signaling and several Notch-dependent developmental processes.
      
 0.673
Tsp86D
Tetraspanin 86D (Tsp86D) encodes a member of the tetraspanin superfamily. With two other tetraspanins, encoded by Tsp3A and Tsp26A, it regulates the trafficking of the product of kuz and consequently Notch signaling and several Notch-dependent developmental processes.
      
 0.672
bin3
Probable RNA methyltransferase bin3; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it (Probable). Required for dorso-ventral patterning in oogenesis and for anterior-posterior pattern formation during embryogenesis, possibly by binding and stabilizing 7SK RNA, thereby promoting formation of a repressive RNA-protein complex.
      
 0.667
daw
Dawdle, isoform A; Dawdle (daw) encodes an Activin- like ligand of the TGF beta superfamily that is required for proper tricarboxylic acid cycle function in the fat body and also regulates insulin release from IPC neurons.
    
 
 0.526
CG11563
MIP13505p1; RNA binding. It is involved in the biological process described with: ribosomal large subunit biogenesis.
      
 0.523
Tsp2A
Tetraspanin-2A; Required for assembly of smooth septate junctions (sSJs), together with Ssk and mesh. Important for barrier function of the midgut epithelium; Belongs to the tetraspanin (TM4SF) family.
   
  
 0.515
GlyP
Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). Required for glycogen breakdown in skeletal muscle.
   
  
 0.470
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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