STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp9b2Cytochrome P450 9b2; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (505 aa)    
Predicted Functional Partners:
Cyp304a1
Probable cytochrome P450 304a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.717
CG14661
Uncharacterized protein, isoform A.
   
  
 0.627
Ugt303B3
UDP-glycosyltransferase family 303 member B3; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity.
   
 
 0.542
sad
Shadow (sad) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 2 carbon of the cholesterol ring. sad mutants fail to undergo head involution, dorsal closure or to secrete cuticle.
  
 
   0.536
smp-30
Senescence marker protein-30 (smp-30) encodes a calcium binding protein involved in calcium homeostasis regulation. It negatively influences cell proliferation and tissue size, possibly through the insulin pathway. It contributes to body size variation, diapause and thermal stress resistance.
   
  
 0.536
CG31673
LD14730p; Glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; hydroxypyruvate reductase activity. It is involved in the biological process described with: oxidation-reduction process; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
      
 0.533
CG7798
GEO02684p1; Lysozyme activity. It is involved in the biological process described with: defense response to Gram-negative bacterium; Belongs to the glycosyl hydrolase 22 family.
      
 0.533
CG32984
Uncharacterized protein; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction.
      
 0.530
shd
Ecdysone 20-monooxygenase; Shade (shd) encodes 20-hydroxylase and is responsible for converting Ecdysone into 20-hydroxyecdysone, the active form of the steroid. It is required in all tissues that produce active Ecdysone and thus contributes to larval moulting, metamorphosis, growth, neuroblast diversity and egg chamber maturation; Belongs to the cytochrome P450 family.
  
 
   0.524
Ugt37A2
UDP-glycosyltransferase family 37 member A2; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups.
   
 
 0.521
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (38%) [HD]